|
|
Michele S. Marcolongo, Ph.D.
[Update My Profile]
Assistant Professor, Materials Engineering
Assistant Professor, School of Biomedical Engineering, Science & Health Systems
Office: Lebow 27-444 Email: marcolms@drexel.edu
Phone: 215.895.2329 Fax: 215.895.6760
Personal Web Page: Click Here to Visit Personal Web Page
Research Keywords:
Biomaterials, resorbable materials, bioactive materials, biocomposite, materials, orthopaedics.
Biosketch:
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Michele S. Marcolongo, Ph.D. P.E. POSITION TITLE
Associate Professor
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
University of Delaware, Newark, DE BS 1986 Mechanical Engineering
Drexel University, Philadelphia, PA MS 1989 Mechanical Engineering
University of Pennsylvania, Philadelphia, PA MS 1992 Bioengineering
University of Pennsylvania, Philadelphia, PA PhD 1995 Bioengineering
A. Positions and Honors.
POSITIONS AND EMPLOYMENT
1986-1990 GENERAL ELECTRIC AEROSPACE, Philadelphia, Pennsylvania
Mechanical Design Engineer (1988-1990)
Space Technology Engineering Program (1986-1988):
1990-1994 UNIVERSITY OF PENNSYLVANIA, Philadelphia, Pennsylvania
Research Fellow(1990-1994)
Biomechanics Laboratory Supervisor (1991-1994)
1994-1997 DEPUY DUPONT ORTHOPAEDICS, Newark, Delaware
Biomedical Research Engineer
1997- Present DREXEL UNIVERSITY, Department of Materials Science and Engineering with appointments in Biomedical and Mechanical Engineering, Philadelphia, PA
Assistant Professor (1997-2004)
Associate Professor (2004-Present)
Associate Vice Provost for Research (2006-Present, half-appointment)
2002-2004 GELIFEX, Philadelphia, PA
Chairman and Co-Founder, sold to Synthes Spine (2004)
HONORS AND AWARDS
NIH Nanotechnology in Medicine Study Section (2007), Editorial Board, J. Biomed. Mater. Res (2007- ), Frontiers in Engineering (NAE) participant, 2007, Appointed to Presidential Advisory Council, Society for Biomaterials, 2006-2007; Orthopaedic Research Society, Hip Society Award: Otto Aufranc Award, 2006; President, Philadelphia Spine Research Society, 2005-Present; Synthes Spine Board Member, Non-fusion Technologies, 2004-Present; Chair for the Society for Biomaterials Orthopaedic Special Interest Group, 2005-2006; Member, NIH Center for Scientific Review, NIBIB, Biomaterials and Biosurfaces, 2005-Present; Drexel University, College of Engineering Outstanding Teacher Award 2003; Society for Biomaterials Participation and Leadership Recognition for Program Chair for Orthopaedic Special Interest Group, 2002; Member, NIH Center for Scientific Review, ZRG1 SSS-5 915) SBIR/STTR Orthopedic Medicine: 2001-Present; Research Fellowship, 1991-1994, University of Pennsylvania Research Fellowship, 1990-1991; GE Re-entry Systems General Manager Employee Recognition Award, 1988; Licensed Professional Engineer, State of PA (1998-Present); GE RE-entry Systems Cost Improvement Awards for Increased Production Efficiency, 1987; Pi Tau Sigma Engineering Honor Society, 1985
PATENTS
1. Marcolongo, M, Lowman, A., M . Keane, E. Vresilovic and Clemow, A, "Hydrogel balloon prosthesis for nucleus pulposus", pending.
2. Marcolongo, M, Lowman, A., and Ho,E., "Bioactive thermogelling polymers", pending.
3. Lowman, A., Marcolongo, M., and Clemow, A., “Thermogelling polymer blends for biomaterial applications”, pending.
4. Marcolongo, M., and Lowman, A.,”Hydrogel copolymers for nucleus pulposus replacement in intervertebral discs”, #7,214,245 (2007).
5.Marcolongo,M., Ducheyne, P., Ko, F., and LaCourse, W.,“Composite Materials using bone bioactive glass and ceramic fibers”,Patents #5,468,544 (1995); 5, 645,934 (1997); 5,721,049 (1998); #6,121,172 (2000).
6.Marcolongo, M., DiMaio, W., and Weiss, A. P., “Anatomically neutral joint”, Patent#5,824,095 (1998).
B. SELECTED PEER-REVIEWED PUBLICATIONS (IN CHRONOLOGICAL ORDER)
1. Marcolongo, M., Ducheyne, P.,and LaCourse, W., “Surface reaction layer formation in vitro on a bioactive glass fiber/polymeric composite”, J. Biomed. Mater. Res, 37, 440-448, 1997.
2. Marcolongo,M., Ducheyne, P., and Garino,J., “Bioactive glass fiber polymeric composites bond to bone tissue”, J. Biomed. Mater. Res., 39, 161-170, 1998.
3. Marcolongo, M., DiNardo, J., Hickok, N., Pourezzaei, K., Beard, R., Brennan, D.J., Heipp, P.S., Phan, T., Protein adsorption and conformation and cellular attachment on biomaterials surfaces as a function of surface charge in Biomedical Materials-Drug Delivery, Implants, and Tissue Engineering, Neenan, T.X., Valentini, R., and Marcolongo, M., Eds. Volume 550 MRS Conference Proceedings, Materials Research Society, Warrendale, PA, May, 1999.
4. Thomas, J., Lowman, A., and Marcolongo, M., “Novel associated hydrogels for nucleus pulposus replacement”, J. Biomed. Mater. Res., 67A:1329-1337, 2003.
5. Kurtz, A.M, Hozack, W., Marcolongo, M., Turner, J., Edidin, A. and Rimnac, C.,”In vivo degradation of mechanical properties and wear performance of UHMWPE acetabular liners, J. Arthroplasty, 18(7), Sup. 1 68-78, 2003.
6. Thomas, J., Gomes, K., Lowman, A., and Marcolongo, M., “The effect of dehydration history on PVA/PVP hydrogels for nucleus pulposus replacement”, J. Biomedical Materials Research Part B: Applied Biomaterials 69B: 135-140, 2004.
7. Katta, J.K., Marcolongo, M.S., Lowman A.M. and Mansmann, K.A.,"Friction and wear characteristics of PVA/PVP hydrogels for articular cartilage", Proc. IEEE 3, 142-143, 2004.
8. Kurtz, S. M., Rimnac,C.M., Hozack.W., Turner, J., Marcolongo, M. Goldberg, V.M., Kraay, M., and Edidin, A.A., "In vivo degradation of polyethylene liners after gamma sterilization in air", J. Bone and Jt. Surg., 87A: 815-823, 2005.
9. A. Joshi, Methta, S., Vresilovic, E., Karduna, A., and Marcolongo, M., “Nucleus implant parameters significantly change the compressive stiffness of the human lumbar intervertebral disc", Trans. of the ASME, 127: 536-540, 2005.
10. Ho, E. and Marcolongo, M., " Effect of coupling agents on the local mechanical properties of bioactive dental composites by the nano-indentation technique", Dental Mater., 21: 656-644 (2005).
11. Fussell, G., Thomas, J., Scanlon, J., Lowman, A., and Marcolongo, M., "The Effect of Protein-Free versus Protein-Containing Media on the Uptake of Ions in PVA/PVP Hydrogels", J. Biomater. Sci.: Polym. Edn., 16(4): 489-503, 2005.
12. Ho, E. and Marcolongo, M. "The role of interfacial mechanics in the prediction of global mechanical behavior of a bioactive composite: an in vitro study", J. Oral Implantology ,XXXII (2) 64-71 (2006).
13. Joshi, A, Fussell, G, Thomas, J, Hsuan, A, Lowman, A, Karduna, A, Vresilovic, E, Marcolongo, M, "Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement," Biomaterials 27: 176-184 , 2006.
14. Ho, E., Lowman, A. and Marcolongo, M, "Synthesis and characterization of an injectable hydrogel with tunable mechanical properties for soft tissue repair", Biomacromolecules, (7) 3223-3228, 2006.
15. Otto Aufranc Award Paper: Kurtz,S.M., Hozack, W., Purtill, J., Marcolongo, M, Kraay, M., Goldberg, V., Sharkey, P., Parvizi, J., Rimnac,C., Edidin, A., "Significance of in vivo degradation for polyethylene in total hip arthoplasty", Clin Ortho. And Rel. Res., 459: 47-57, 2006.
16. Perea, W., Cannella, M., Vega, A., Polenova, T., and Marcolongo, M., "2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc.", Mag. Res. in Med.,57:990-999, 2007.
17. Ho, E., Lowman, A., and Marcolongo, M., "In situ apatite forming injectable hydrogel", Journal of Biomed., Mater. Res., Journal of Biomedical Materials Research Part A 83A(1): 249-256, 2007.
18. Katti, J., Marcolongo, M., Lowman, A., Mannsman, K., " Friction and wear behavior of PVA/PVP hydrogels for articular cartilage replacement”, Journal of Biomedical Materials Research Part A 83A(2): 471-479, 2007.
19. Liu, X., Marcolongo, M., and Lowman, A., ”Short term in vitro response of associating hydrogels”, Journal of Applied Polymer Science, accepted.
20. Ooms, K.J., Cannella, M., Vega, A. J., Marcolongo, M., Polenova, T., “The application of 23Na DQF NMR spectroscopy for the study of spinal disc degeneration”, Mag. Res. in Med., in press.
21. Joshi,A., Vresilovic, E., Cannella, M., Arthur, A., Karduna, A., Marcolongo, M., "The effect of partial denulceation on the mechanical behavior of the intervertebral disc", J. Biomech., in press.
22. Joshi, A., Massey, C., A. Karduna, E. Vresilovic, Marcolongo, M., “The Effect of Nucleus Implant Parameters on the Compressive Mechanics of the Lumbar Intervertebral Disc: A Finite Element Study”, J. Biomed. Mater. Res (B), in revision.
23. Thomas, J., Sarkar, S., Lowman, A.M., Marcolongo, M., “The effect of branched or grafted PEG/PNIPAAm hydrogels on quasi-static compression and mechanical recovery”, Biomaterials, submitted.
24. Arthur, A., Cannella, M., Keane, M., Singhatat, W., Vresilovic, R., and Marcolongo, M., “Fill of the nucleus cavity affects mechanical stability in compression, bending and torsion of a spine segment which has undergone nucleus replacement”, Spine, submitted.
25. Cannella, M., Orana, A., Vresilovic, E., and Marcolongo, M., “Nucleus pulposus augmentation creates a linear relationship among implant volume, disc height and intradiscal pressure”, Spine, submitted.
26. Cannella, M., Allen, S., Vresilovic, E., and Marcolongo, M., “Partial denucleation and subsequent implantation of the nucleus pulposus is able to restore intact compressive mechanics”, J. Biomech., submitted.
27. Rothstein, D., Robertson, N., Jost, M., Marcolongo, M., “Model cell lines for the study of primary blastocyst attachment to the uterine epithelium”, submitted.
28. Thomas, J., Sarkar, S., Lowman, A.M, Marcolongo, M., “Injectable structural hydrogels for intervertebral disc implantation”, J. Biomed. Mater. Res., submitted.
29. Ooms, K.J., Cannella, M., Vega, A.J. Marcolongo, M., Polenova, T., “23Na TQF NMR imaging for the study of spinal disc tissue”, JMR, submitted.
30. Baxter, R.M., Steinbeck, M.J., Tipper, J.L., Rimnac, C.M., Parvizi, J., Marcolongo, M.,Kurtz, S. M., “Comparison of Periprosthetic Tissue Digestion Methods for Polyethylene Wear Particle Extraction, J. Biomed. Mater. Res., submitted.
C. RESEARCH SUPPORT
ONGOING RESEARCH SUPPORT
Synthes 04/01/04-07/31/08
Mechanical Behavior of Hydrogels for Nucleus Replacement
Study of cadaver nucleus implant biomechanics and numerical modeling of viscoelastic behavior of the intervertebral disc.
Role: Principal Investigator
2 R01 AR47904.01 07/01/05-06/30/10
NIH NIAMS
Mechanics and Performance of Traceable UHMWPE Implants
This continuing grant allows study of the in vivo degradation of UHMWPE acetabular cups through a multi-center retrieval program.
Role: Co-Principal Investigator
NSF 07/01/07-06/30/10
Understanding Cell Damage During 3D Printing
Analysis of damage mechanisms associated with 3D printing of cells in scaffolds.
Role: Co-Principal Investigator
State of PA Tobacco Settlement Grant 01/01/08-12/31/09
Modeling L-selectin mediated attachment strength during embryo implantation
Role: Co-Principal Investigator
COMPLETED RESEARCH SUPPORT
NFL Charities 01/-1/06-6/30/07
The Role of Bound Water in Intervertebral Disc Degeneration
This work examines the role of bound water in the physico-chemical properties of the nucleus pulposus in disc degeneration. It also looks at alternate strategies for diagnosing early degenerative disc disease.
Role: Principal Investigator
Drexel Women's Leadership Initiative 09/1/04-12/31/06
Mechanisms Responsible for Blastocyst Attachment
Internal synergy grant aimed at promoting research on women's health issues, this grant focuses on the protein interactions responsible for blastocyst implantation in the uterus.
Role: Principal Investigator
1 R01 AR47904.01 08/01/01-07/31/04
NIH NIAMS
Mechanics and Performance of Traceable UHMWPE Hip Implants
This work allows us to trace and analyze UHMWPE hip cups to identify mechanical and chemical mechanisms associated with alterations in material properties and clinical performance.
Role: Co-Investigator
NSF BES 8/1/02-7/31/05
Environmental Scanning Electron Microscope for Cellular and Biopolymer Interactions
This work enabled acquisition of an ESEM for University.
Role: Co-Investigator
Gelifex 04/01/03-12/31/03
Thermoreversible Hydrogel Synthesis and Characterization
This work supported formulation and characterization of thermoreversible hydrogels for orthopaedics.
Role: Principal Investigator
NSF BES 10/1/00-9/30/03
Functional Restoration of the Nucleus Pulposus of the Intervertebral Disc Using Hydrogel Polymer Blends
The objective of this work is to evaluate different copolymer compositions to determine optimal properties of mechanical integrity and in vitro stability. We will fabricate prototypes and insert them into cadaveric models using arthroscopic techniques. These implant/spine segment composites will be mechanically tested in bending and torsion and the performance compared to intact spinal segments.
Role: Principal Investigator
Sharp Foundation Grant 9/1/01-8/31/03
Tribological Characterization of Hydrogels for Bearing Surfaces
In this program, we investigate the wear and frictional characteristics of hydrogels intended for arthroscopic joint replacement.
Role: Co-Investigator
NSF EEC9980298 10/1/99-9/30/02
Research and Curriculum Development in Tissue Engineering
The objective of this program is to enhance and expand our graduate student education through classroom and research experience in the field of tissue engineering. My contribution is biomaterials structure and characterization as well as surface interactions between the material and the physiological environment.
Role: Co-Investigator
1RO3AR45792-01 10/1/98-9/30/01
NIH NIAMS
Electrostatic surface optimization for osseointegration
The goal of this work was to quantify the differences in cellular attachment and protein adhesion to biomaterials surfaces due to local surface charges (on the order of the cell and protein).
Role: Principal Investigator
Therics, Inc., Princeton, NJ 4/01/01-03/31/03
Mechanical Response of 3-D Printed Composites
The goal of this program is to define the mechanical behavior of composites intended for tissue engineering of bone through long-term mechanical testing and numerical modeling.
Role: Principal Investigator
Education:
University of Delaware, Newark, DE BS 1986 Mechanical Engineering
Drexel University, Philadelphia, PA MS 1989 Mechanical Engineering
University of Pennsylvania, Philadelphia, PA MS 1992 Bioengineering
University of Pennsylvania, Philadelphia, PA PhD 1995 Bioengineering
Publications:
1. Marcolongo, M., Ducheyne, P.,and LaCourse, W., “Surface reaction layer formation in vitro on a bioactive glass fiber/polymeric composite”, J. Biomed. Mater. Res, 37, 440-448, 1997.
2. Marcolongo,M., Ducheyne, P., and Garino,J., “Bioactive glass fiber polymeric composites bond to bone tissue”, J. Biomed. Mater. Res., 39, 161-170, 1998.
3. Marcolongo, M., DiNardo, J., Hickok, N., Pourezzaei, K., Beard, R., Brennan, D.J., Heipp, P.S., Phan, T., Protein adsorption and conformation and cellular attachment on biomaterials surfaces as a function of surface charge in Biomedical Materials-Drug Delivery, Implants, and Tissue Engineering, Neenan, T.X., Valentini, R., and Marcolongo, M., Eds. Volume 550 MRS Conference Proceedings, Materials Research Society, Warrendale, PA, May, 1999.
4. Thomas, J., Lowman, A., and Marcolongo, M., “Novel associated hydrogels for nucleus pulposus replacement”, J. Biomed. Mater. Res., 67A:1329-1337, 2003.
5. Kurtz, A.M, Hozack, W., Marcolongo, M., Turner, J., Edidin, A. and Rimnac, C.,”In vivo degradation of mechanical properties and wear performance of UHMWPE acetabular liners, J. Arthroplasty, 18(7), Sup. 1 68-78, 2003.
6. Thomas, J., Gomes, K., Lowman, A., and Marcolongo, M., “The effect of dehydration history on PVA/PVP hydrogels for nucleus pulposus replacement”, J. Biomedical Materials Research Part B: Applied Biomaterials 69B: 135-140, 2004.
7. Katta, J.K., Marcolongo, M.S., Lowman A.M. and Mansmann, K.A.,"Friction and wear characteristics of PVA/PVP hydrogels for articular cartilage", Proc. IEEE 3, 142-143, 2004.
8. Kurtz, S. M., Rimnac,C.M., Hozack.W., Turner, J., Marcolongo, M. Goldberg, V.M., Kraay, M., and Edidin, A.A., "In vivo degradation of polyethylene liners after gamma sterilization in air", J. Bone and Jt. Surg., 87A: 815-823, 2005.
9. A. Joshi, Methta, S., Vresilovic, E., Karduna, A., and Marcolongo, M., “Nucleus implant parameters significantly change the compressive stiffness of the human lumbar intervertebral disc", Trans. of the ASME, 127: 536-540, 2005.
10. Ho, E. and Marcolongo, M., " Effect of coupling agents on the local mechanical properties of bioactive dental composites by the nano-indentation technique", Dental Mater., 21: 656-644 (2005).
11. Fussell, G., Thomas, J., Scanlon, J., Lowman, A., and Marcolongo, M., "The Effect of Protein-Free versus Protein-Containing Media on the Uptake of Ions in PVA/PVP Hydrogels", J. Biomater. Sci.: Polym. Edn., 16(4): 489-503, 2005.
12. Ho, E. and Marcolongo, M. "The role of interfacial mechanics in the prediction of global mechanical behavior of a bioactive composite: an in vitro study", J. Oral Implantology ,XXXII (2) 64-71 (2006).
13. Joshi, A, Fussell, G, Thomas, J, Hsuan, A, Lowman, A, Karduna, A, Vresilovic, E, Marcolongo, M, "Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement," Biomaterials 27: 176-184 , 2006.
14. Ho, E., Lowman, A. and Marcolongo, M, "Synthesis and characterization of an injectable hydrogel with tunable mechanical properties for soft tissue repair", Biomacromolecules, (7) 3223-3228, 2006.
15. Otto Aufranc Award Paper: Kurtz,S.M., Hozack, W., Purtill, J., Marcolongo, M, Kraay, M., Goldberg, V., Sharkey, P., Parvizi, J., Rimnac,C., Edidin, A., "Significance of in vivo degradation for polyethylene in total hip arthoplasty", Clin Ortho. And Rel. Res., 459: 47-57, 2006.
16. Perea, W., Cannella, M., Vega, A., Polenova, T., and Marcolongo, M., "2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc.", Mag. Res. in Med.,57:990-999, 2007.
17. Ho, E., Lowman, A., and Marcolongo, M., "In situ apatite forming injectable hydrogel", Journal of Biomed., Mater. Res., Journal of Biomedical Materials Research Part A 83A(1): 249-256, 2007.
18. Katti, J., Marcolongo, M., Lowman, A., Mannsman, K., " Friction and wear behavior of PVA/PVP hydrogels for articular cartilage replacement”, Journal of Biomedical Materials Research Part A 83A(2): 471-479, 2007.
19. Liu, X., Marcolongo, M., and Lowman, A., ”Short term in vitro response of associating hydrogels”, Journal of Applied Polymer Science, accepted.
20. Ooms, K.J., Cannella, M., Vega, A. J., Marcolongo, M., Polenova, T., “The application of 23Na DQF NMR spectroscopy for the study of spinal disc degeneration”, Mag. Res. in Med., in press.
21. Joshi,A., Vresilovic, E., Cannella, M., Arthur, A., Karduna, A., Marcolongo, M., "The effect of partial denulceation on the mechanical behavior of the intervertebral disc", J. Biomech., in press.
22. Joshi, A., Massey, C., A. Karduna, E. Vresilovic, Marcolongo, M., “The Effect of Nucleus Implant Parameters on the Compressive Mechanics of the Lumbar Intervertebral Disc: A Finite Element Study”, J. Biomed. Mater. Res (B), in revision.
23. Thomas, J., Sarkar, S., Lowman, A.M., Marcolongo, M., “The effect of branched or grafted PEG/PNIPAAm hydrogels on quasi-static compression and mechanical recovery”, Biomaterials, submitted.
24. Arthur, A., Cannella, M., Keane, M., Singhatat, W., Vresilovic, R., and Marcolongo, M., “Fill of the nucleus cavity affects mechanical stability in compression, bending and torsion of a spine segment which has undergone nucleus replacement”, Spine, submitted.
25. Cannella, M., Orana, A., Vresilovic, E., and Marcolongo, M., “Nucleus pulposus augmentation creates a linear relationship among implant volume, disc height and intradiscal pressure”, Spine, submitted.
26. Cannella, M., Allen, S., Vresilovic, E., and Marcolongo, M., “Partial denucleation and subsequent implantation of the nucleus pulposus is able to restore intact compressive mechanics”, J. Biomech., submitted.
27. Rothstein, D., Robertson, N., Jost, M., Marcolongo, M., “Model cell lines for the study of primary blastocyst attachment to the uterine epithelium”, submitted.
28. Thomas, J., Sarkar, S., Lowman, A.M, Marcolongo, M., “Injectable structural hydrogels for intervertebral disc implantation”, J. Biomed. Mater. Res., submitted.
29. Ooms, K.J., Cannella, M., Vega, A.J. Marcolongo, M., Polenova, T., “23Na TQF NMR imaging for the study of spinal disc tissue”, JMR, submitted.
30. Baxter, R.M., Steinbeck, M.J., Tipper, J.L., Rimnac, C.M., Parvizi, J., Marcolongo, M.,Kurtz, S. M., “Comparison of Periprosthetic Tissue Digestion Methods for Polyethylene Wear Particle Extraction, J. Biomed. Mater. Res., submitted.
Patents:
1. Marcolongo, M, Lowman, A., M . Keane, E. Vresilovic and Clemow, A, "Hydrogel balloon prosthesis for nucleus pulposus", pending.
2. Marcolongo, M, Lowman, A., and Ho,E., "Bioactive thermogelling polymers", pending.
3. Lowman, A., Marcolongo, M., and Clemow, A., “Thermogelling polymer blends for biomaterial applications”, pending.
4. Marcolongo, M., and Lowman, A.,”Hydrogel copolymers for nucleus pulposus replacement in intervertebral discs”, #7,214,245 (2007).
5.Marcolongo,M., Ducheyne, P., Ko, F., and LaCourse, W.,“Composite Materials using bone bioactive glass and ceramic fibers”,Patents #5,468,544 (1995); 5, 645,934 (1997); 5,721,049 (1998); #6,121,172 (2000).
6.Marcolongo, M., DiMaio, W., and Weiss, A. P., “Anatomically neutral joint”, Patent#5,824,095 (1998).
|
|
|
|
