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Richard F Rest
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Professor, Microbiology
Email: richard.rest@drexel.edu
Phone: 215.991.8382 Fax: 215.848.2271
Active Research Projects:
Molecular & cellular mechanisms of the pathogenesis of Neisseria gonorrhoeae, Neisseria meningitidis, and Bacillus anthracis. Role of the Opa outer membrane protein family in cell association and intracellular survival of N. gonorrhoeae and N. meningitidis. Regulation of lipopolysaccharide (LPS) sialylation, and expression of sialyltransferase, in N. gonorrhoeae and N. meningitidis. The role of LPS sialylation in gonococcal and meningococcal virulence. Mechanisms of transport of sialyltransferase to the neisserial outer membrane. The role of Anthrolysin O in the interactions of B. anthracis with macrophages, neutrophils and other human cells. Building a better detector for biodefense and homeland security, focusing on agents of bioterrorism, biowarfare and emerging infectious diseases.
Publications:
Williams, J.M., L. Zhu, G.-C. Chen and R.F. Rest. 1998. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: Intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. Molec Microbiol, 27:171-186.
Hood, D. W., K. Makepeace, M. E. Deadman, R. F. Rest, P. Thibault, A. Martin, J. C. Richards, & E. R. Moxon. 1999. Sialic acid in the lipopolysaccharide of Haemophilus influenzae: strain distribution, influence on serum resistance and structural characterization. Molec. Microbiol. 33:679-692.
Liu, S. V., N. J. Saunders, A. Jeffries and R.F. Rest. 2002. Genome analysis and strain comparison of Correia repeats and Correia Repeat-Enclosed Elements (CREE) in pathogenic neisseria. J. Bacteriology, 184:6163-6173
Shell, D., D. Chiles, R. Judd, S. Seal and R.F. Rest. 2002. Outer membrane localization of sialyltransferase in the pathogenic Neisseria. Infect Immun 70:3744-3751.
J. G. Shannon, C. L. Ross, T. M. Koehler and R. F. Rest. 2002. Characterization of Anthrolysin O, the Bacillus anthracis Cholesterol-Dependent Cytolysin. Infect. Immun. submitted
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