|
|
Aydin Tozeren, Ph.D.
[Details]
[Update My Profile]
Distinguished Professor and Director, Center for Integrated Bioinformatics, School of Biomedical Engineering, Science & Health Systems
Office: Bossone 7-711 Email: aydin.tozeren@drexel.edu
Phone: 215.895.6148
Laboratory Web Page: Click Here to Visit Laboratory Web Page
Research Keywords:
Breast cell adhesion and communication, signal transduction networks in cancer and epithelial cells; integrated bioinformatics, molecular profiling, 3D-tumors, bioimaging.
Biosketch:
Dr. Aydin Tozeren, Professor of Biomedical Engineering at Drexel University and Co-Director of the Greater Philadelphia Bioinformatics Alliance, received his Ph.D. from Columbia University in 1974 and has been a full professor at CUA since 1990. Previously, he held academic and research positions at Columbia University and the National Institutes of Health. He published in the areas of cell adhesion and signaling, molecular basis of muscle contraction, biomechanics, and the mathematical modeling of biological systems. Dr. Tozeren's book Human Body Dynamics: Classical Mechanics and Human Movement received the best engineering title award for the year 2000 by the Amarican Association of Publishers. His upcoming book, New Biology for Engineers and Computer Scientists will be published by Prentice Hall. Dr. Tozeren received and directed research grants from the National Science Foundation, the National Institutes of Health, Department of Defense Breast Cancer Research Fund, and an biomedical engineering infrastructure special opportunity grant from the Whitaker Foundation. Dr. Tozeren taught a large number of graduate and undergraduate courses, guided doctoral dissertations, and received in 1996, the Alpha Delta Gamma Outstanding Teacher Award at the Catholic University of America. In the year 2001, he served as member at the Board of Scientific Advisors of the Whitaker Foundation.
Awards:
Alpha Delta Gamma Outstanding Instructor Award in 1996
Best Engineering Title for 2000 award for Human Body Dynamics by the Association for American Publishers (http://www.pspcentral.org./).
Member, Acadamic Council, AIMBE
Guest Member, Board of Scientific advisors, Whitaker Foundation
Director, Whitaker Foundation Special Opportunity Grant 1999-2002
Grants from NSF and NIH
Education:
PH.D., Columbia University, Bioengineering concentration, 1974
M.S., Columbia University, Engineering mechanics, 1972
B.S., Orta Dogu Technical University, Ankara, TR, 1971
Active Research Projects:
Origin and evolution of cell phenotypes in growing breast tumors
Bioinformatics of chromosome aberrations in breast cancer
Automated histology of breast cancer
Publications:
Books:
Human Body Dynamics: Classical Mechanics & Human Movement (1999), Aydin Tozeren,
Springer-Verlag, New York, NY.
New Biology for Engineers and Computer Scientists (April 2003), Aydin Tozeren and SW Byers, Prentice Hall, NJ.
Selected Journal Articles (since 1990):
1. Tozeren, A., Cell-Cell Conjugation: Transient Analysis and Experimental Implications, Biophys. J., 58:641-652, (1990).
2. Tozeren, A., Cell-Cell, Cell-Substrate Adhesion: Theoretical and Experimental Considerations, J. Biomech. Engr., 112:311-318, (1990).
3. Tozeren, A., K.L.P. Sung, L.A. Sung, M.L. Dustin, P-Y. Chan, T.A. Springer and S. Chien, Micromanipulation of Adhesion of a Jurkat Cell to a Planar Membrane Containing either Mobile or Immobile LFA-3 Molecules, J. Cell Biol., 116:997-1006 (1992).
4. Tozeren, A., L.H. Mackie, M.B. Lawrence, P-Y. Chan, M.L. Dustin and T.A. Springer, The Interaction of PMA-stimulated T Lymphocytes with Planar Membranes Containing Intercellular Adhesion Molecules, Biophys. J., 63:247-258 (1992).
5. Tozeren, A. and K. Ley, How Do Selectins Mediate Leukocyte Rolling in Blood Vessels?, Biophys. J., 63:700-709 (1992).
6. Tozeren, A., H.K. Kleinman, S. Wu, A.M. Mercurio and S.W. Byers, Integrin ƒp6ƒr4 Mediates Dynamic Interactions with Laminin, J. Cell Science, 107: 3153-3163 (1994).
7. Tozeren, A., Cell Tumbling in Laminar Flow: Cell Velocity is a Unique Function of the Shear Rate. Cellular Mechanics and Cellular Engineering, Ed. V. C. Mow, F. Guilak, R. Tran-Son-Tay, and R.M. Hochmuth., Springer and Verlag (1994).
8. Tozeren, A., H.K. Kleinman, D.S. Grant, D. Morales, A.M. Mercurio, and S.W.Byers, E-Selectin-Mediated Dynamic Interactions of Breast and Colon Cells With Endothelial-Cell Monolayers, Int. J. Cancer, 60: 426-431 (1995).
9. Ozerdem, B. and A. Tozeren, Collagen Gels Have Instantaneous Elasticity, ASME J. Biomechanical Engineering, 117: 397-402 (1995).
10. Byers, S.W., C.L. Sommers, B. Hoxter, A.M. Mercurio, and A. Tozeren, The Role of E-Cadherin in the Response of Tumor Cell Aggregates to Lymphatic, Venous and Arterial Flow: Measurement of Cell-Cell Adhesion Strength, J. Cell Sci., 108: 2053-2064, (1995).
11. Tozeren, A. Biophysical Parameters of Leukocyte Adhesion to Vascular Endothelium , Physiology and Pathophysiology of Leukocyte Adhesion, Ed. D. Neil Granger and Geert W. Schmid-Schonbein, Oxford University Press, New York (1995).
12. Brooks, S. and A. Tozeren, Laminar Flow Past an Array of Cells That are Adherent to the Bottom Plate of a Flow Channel, Computations and Fluids 25: 741 - 757 (1996).
13. Byers, S.W., Pishvaian, M., Crockett, C., Peer, C., Tozeren, A., Sporn, M., Anzano, M., Leichleider, R., Retinoids Increase Cell-Cell Adhesion Strength, b-Catenin Protein Stability and Localization to the Cell Membrane in a Breast Cancer Cell Line: A Role for Serine Kinase Activity. Endocrinology 137:3265-3274, (1996).
14. Damiano, E.R., J. Westheider, A. Tozeren, and K. Ley, Variation in the Velocity, Deformation, and Adhesion Energy Densities of Leukocytes Rolling Within Venules, Circulation Research 79: 1122-1130, (1996).
15. Wu, S., Hoxter, B. Byers, S.W., and A. Tozeren. Role of Cytoskeleton and Deformability in Laminin-mediated Rolling. Biorheology 35: 37-51, (1998).
16. Tozeren, A., Wu, S., Hoxter, B., Adamson, E.D., and S.W. Byers. Vinculin and Cell to Cell Adhesion. Cell Adhesion and Communication 5: 49-59, (1998).
17. Petushi, S., Katsinis, C., Coward C., Garcia U.F., Tozeren A., Automated Identification of Microstructures on Histology Slides. Proceedings of EEE International Symposium in Biomedical Imaging, U.S.A. April 2004.
18. Tozeren, A, Coward C., Petushi, S., 2004. Origins and Evolution of Cell Phenotypes in Breast Tumors. J Theor. Biology (in review)
19. Petushi, S., Garcia U.F., Katsinis, C., Tozeren A., 2004. Large-Scale Computations on Breast Cancer Histology Images. J. Computerized Medical Imaging and Graphics. (in review)
|
|
|
|
