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BIOMED Faculty Details: Peter I. Lelkes, Ph.D.
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Peter I. Lelkes, Ph.D.   [Update My Profile]
Visiting Research Professor and Distinguished Calhoun Scholar, School of Biomedical Engineering, Science & Health Systems
Office: New College Bldg - 14309  Email: pilelkes@drexel.edu
Phone: 215.895.2219   Fax: 215.895.4893
Research Keywords:
3-D Tissue Engineering: scaffolds,,solid-free-form fabrication, smart biomaterials, decelluarized matrices,tissue-specific differentiation, vascularization of engineered tissues,bioreactors. Stem Cell Research: Target differentiation of embryonic and adult stem cells for lung, cardiac, spinal cord and musculoskeletal tisue engineering and regenerative medicine. Space biology: (simulated) microgravity, space flight, NASA Other interests: neurodegenerative diseases, cardiovascular pathophysiology, biomatrices, cell-biomaterials interactions, artificial internal organs, endothelial cell biology, hemodynamic forces, atherosclerosis, genomics, signal transduction.
Personal News:
2005 - to date: NTI-Nanotechnology Institute - Tissue Engineering Initiative
2007 - to date: Coulter projects in translational Biomedical Engineering: Vascular Grafts, "Green Prptein" Scaffolds
2008- to date: Scientific Director, Surgical Engineering Enterprise, DUCOM Strategic Initiative
2008: Drexel Research Award
2008: BIOMED Teaching Award
Biosketch:
Positions Held:
1977 Postdoctoral Fellow - Weizmann Institute of Science, Dept. of Membrane Research, Rehovoth, Israel.
1978-1979 Minerva Fellow - Weizmann Institute of Science, Dept. of Membrane Research, Rehovoth, Israel.
1980-1981 Ministry of Immigration and Absorption Fellow - Weizmann Inst. of Science, Dept. of Membrane Research, Rehovoth, Israel
1981-1984 Staff Member (Scientist) - Weizmann Institute of Science, Dept. of Membrane Research, Rehovoth, Israel.
1983-1984 Visiting Associate, Laboratory of Cell Biology and Genetics, NIADDK, National Institutes of Health, Bethesda, MD.
1985-1988 Visiting Scientist, Laboratory of Cell Biology and Genetics, NIDDK, National Institutes of Health, Bethesda, MD.
1988-1999 Director, Laboratory of Cell Biology, Department of Medicine, University of Wisconsin, Milwaukee Clinical Campus, Milwaukee, WI
1999-2000 Director, Laboratory of Cell Biology, Department of Medicine, University of Wisconsin, Madison, WI
2000-date Director, Laboratory of Cellular Tissue Engineering and Regenerative Medicine, Drexel University, Philadelphia, PA
2007-date Director, Surgical Engineering Enterprises, Drexel University College of Medicine


Faculty Appointments:
July 1, 1988 Associate Professor of Medicine, University of Wisconsin Medical School, Milwaukee Clinical Campus, Milwaukee, WI
Jan. 1, 1990 Adjunct Associate Professor of Cell Biology, Department of Biology, Marquette University, Milwaukee, WI
July 1, 1991 Associate Professor of Medicine, University of Wisconsin Medical School, Madison, WI
July 1, 1993 Professor of Medicine, University of Wisconsin Medical School, Madison, WI
July 1, 1994 Adjunct Professor of Cell Biology, Department of Biology, Marquette University, Milwaukee, WI
Sept.1, 2000 Calhoun Chair Professor of Cellular Tissue Engineering, Drexel University, Philadelphia
Professor of Mechanical Engineering and Mechanics, Drexel University College of Engineering
Professor of Biochemistry and Molecular Biology, Drexel University College of Medicine
Professor of Pathology and Laboratory Medicine, Drexel University College of Medicine
Professor of Surgery, Drexel University College of Medicine

Awards:
1968 Studienstiftung des Deutschen Volkes (German Federal University Scholarship)
1978 Minerva Fellowship
1982 EMBO Visiting Fellowship
1983-1988 Fogarty Visiting Associate/Scientist Fellowship at NIH
1992 NATO Visiting Fellowship
1994 NATO Visiting Fellowship
1997-1998 Lady Davis Visiting Professorship, Hebrew University, Jerusalem
2003-2007 Stein Family Fellowship, Drexel University
2004 Honorary Professor, Changchun Institute of Polymer Chemistry and Physics, Chinese Academy of Sciences
2005 Honorary Professor, University of Applied Sciences Aachen, Germany
2008 Outstanding Research Scholarship Faculty Award, Drexel University
2008 Outstanding Teach Faculty Award, School Of Biomedical Engineering, Science and Health Systems

Professional Societies:
1) International Society for Applied Cardiovascular Biology (ISACB),
(1995-2000, Member of the ISACB Executive Council)
2) North American Vascular Biology Organization (NAVBO)
3) International Tissue Engineering and Regenerative Medicine Society (TERMIS)
4) International Federation of Engineering in Medicine and Biology
(IFMBE, Member Steering Committee Working Group on Cellular Engineering)


Service on Institutional Committees:
1988 - 1999 Executive Faculty Committee, UW Med. School, Milwaukee Clinical Campus
1988 - 1999 Promotion Committee, UW Med. School, Milwaukee Clinical Campus
1991 - 2000 Executive Faulty Committee, UW Med. School, Madison
1993 - 1996 Research Committee, UW Med. School, Madison
2001 - 2005 Drexel University Faculty Senate, Steering Committee
2003 - 2005 Drexel University Tenure Appeals Committee
2005 Member of Dean Güçeri’s 5 Year Review Committee
2005 Chair of Director Onaral’s 5 Year Review Committee
2006- 2009 Drexel University Tenure Appeals Committee



Review panels or committees
NIH Health Reviewers Reserve AHA - Wisconsin - peer review committee
AHA Midwestern Consortium Ad hoc reviewer for NSF, BSF, NIH, US Army
Member, NIH Special Emphasis Panel/Scientific Review Group ZRG1 F05-J
American Institute for Biological Sciences
Chair, Review Panel on Bone-related Diseases
Member, Review Panel on Osteoporosis
Member, Boston CIMIT Review Panel


Service on editorial boards
Journal of Cellular Biochemistry, Guest Editor (1990/1991).
Endothelium (1992-2008)
12/1995 -04/1999: Associate Editor for U.S.A,
5/1999 – 12/2008: Editor-in-Chief
In vitro Cell and Development Biology (1993 -1998)
Biotechnique (1993 –1998)
Angiogenesis (1998 – 2005)


Other professional activities
1990 Organizer, UCLA Symposium "The Endothelial Cell", Keystone, CO.
1991 Co-director, NATO-Advanced Study Institute "Angiogenesis", Porto Hydra,, Greece
1991 Organizer, American Society for Cell Biology Subgroup Meeting "Endothelial Cell Heterogeneity and Organ-specificity", Boston, MA.
1992 Organizer, American Society for Cell Biology Subgroup Meeting "Endothelial Cell Heterogeneity and Organ-specificity", Denver, CO.
1992 Steering Committee, Vascular Biology Interest Group, Milwaukee
1993 Co-director, NATO-Advanced Study Institute "Angiogenesis", Rhodes, Greece
1993 Organizer, American Society for Cell Biology Subgroup Meeting "Endothelial Cell Heterogeneity and Organ-specificity", Denver, CO.
1995 Co-director, NATO-Advanced Study Institute "Angiogenesis", Saloniki, Greece
1995 Member Executive Committee, International Society for Applied Cardiovascular Biology
1996 Organizer, Symposium "Biocompatible Cardiac Prostheses" at the 5th Biannual Meeting of the International Society for Applied l Cardiovascular Biology, Manchester, U.K.
1996 Organizer, Symposium "Cell-Extracellular Matrix Interactions" at the World Conference for In Vitro Biology, San Francisco, CA.
1997 Co-Director, NATO-Advanced Study Institute "Angiogenesis", Rhodes, Greece
1998 Organizer, Keystone Symposium "Angiogenesis", Keystone, CO.
1998 Program Co-Chair, 6th Biannual Meeting, International Society for Applied Cardiovascular Biology, Wildbad Kreuth, Germany
1999 Co-Director, NATO-Advanced Study Institute "Angiogenesis", Crete, Greece
2001 Co-Director, NATO-Advanced Study Institute "Angiogenesis", Crete, Greece
2001 Team Leader, Nanotechnology Tissue Engineering Initiative
2002 Organizer, Symposium Vascular Tissue Engineering, WC2003, Sydney Australia
2003 Organizer, Symposium Cellular Mechanoactivation, 6th ICCE, Sydney Australia
2004 Co-Chair, Program Committee, BMES 2004, Philadelphia, PA
2005 Member Organizing Committee, 7th ICCE, Seoul, South Korea
2006 Member Organizing Committee, WC2006, Seoul, South Korea
2007 Member Organizing Committee International TERMIS Meetings London


Peer Review Panels :

National Institutes of Health
National Science Foundation
American Institute of Biological Sciences
Israel - U.S. Binational Science Foundation
Israel - German (Minerva) Research Foundation


Peer Reviewer for Professional Journals :
American J Pathology American J Respiratory Cell Molec Biology
American J Physiology ASAIO J
Biochimica et Biophysica Acta Biology of Reproduction
Biomaterials
Biotechnique Cell
Circulation
Endocrinology Endothelium
J Biomaterial Science J Cellular Biochemistry
Tissue Engineering Microvascular Research
Research Grants Awarded:
1978-1980 German-Israeli Research Foundation (Minerva)
1980-1982 Israel Academy of Sciences
1982-1983 Israel Ministry of Technology
1988-1991 Mt. Sinai Research Foundation ($ 80,000)
1988-1999 Milwaukee Heart Research Foundation ($ 2,100,000)
1990-1992 American Heart Association - Wisconsin Chapter ($ 100,000)
1990-1993 American Heart Association, National ($ 115,000)
1992-1993 Johnson and Johnson Company ($ 35,000)
1992-1993 Medtronic, Inc. ($ 30,000)
1992-1994 NATO Collaborative Grant ($ 5,000, CoPI)
1992-1996 National Aeronautics and Space Administration (NASA, UG) ($ 640,000)
1993-1994 University of Wisconsin Medical School Research Grant ($ 10,000)
1994-1995 National Aeronautics and Space Administration (NASA, UL) ($ 200,000)
1994-1997 American Heart Association, National ($ 132,000, CoPI)
1994-1996 NATO Collaborative Grant ($ 7,500, CoPI)
1994-1995 Mt. Sinai Medical Research Foundation ($ 10,000)
1995-1997 Berlex Research Foundation ($ 51,500)
1995-1997 Japanese Ministry of Technology Collaborative Grant, CoPI ($ 50,000)
1995-1998 National Aeronautics and Space Administration (NASA. UL) ($ 171,000)
1996-1997 National Aeronautics and Space Administration (NASA. UG), CoPI, ($ 180,000)
1997 American Heart Association Wisconsin Affiliate ($ 30,000)
1998 National Institutes of Health Conference Grant ( $ 17,000)
1998-2000 National Aeronautics and Space Administration (NASA. UL) ($ 150,000)
1998-2000 American Heart Association Wisconsin Affiliate, CoPI ($ 60,000)
1998-2001 American Heart Association, National Center ($ 165,000)
1998-2002 Berlex Research Foundation ($ 275,000)
1999-2002 National Aeronautics and Space Administration (NASA. UG), ($ 680,000)
2001-2005 Berlex Research Foundation ($ 75,000)
2001-2002 Drexel/MCPHU Synergy Grant Cardiac Tissue Engineering ($ 20,000)
2001-2005 Nanotechnology Institute of SE Pennsylvania Tissue Engineering Initiative ($ 300,000)
2002-2004 Drexel Synergy Grants Nano-Neuro-Tissue Engineering ($ 40,000)
2003-2006 National Science Foundation Porogenic Solid FreeformFabrication ($ 300,000 CoPI)
2003-2007 National Aeronautics and Space Administration (NASA. UG), ($ 780,000)
2004-2005 Drexel Synergy Grant, Pulmonary Tissue Engineering ($ 20,000, C. Finck, PI)
2004-2006 Nanotechnology Institute of SE Pennsylvania Tissue Engineering Initiative ($ 200, 000)
2005-2006 Nanotechnology Institute of SE Pennsylvania Plasma TE Engineering ($ 30,000, CoPI)
2004-2007 Stein Family Foundation ($ 80,000)
2005-2007 National Institutes of Health R21 Grant ($ 250,000 CoPI)
2007-2008 Nanotechnology Institute of SE Pennsylvania, Natural Protein Based Scaffolds ($ 30,000)
2007-2008 Coulter Translational Research Foundation ($ 130,000)
2007-2010 National Science Foundation EWOL-based Scaffold Manufacturing ($ 700,000, CoPI)
2007-2012 Drexel University College of Medicine, Surgical Tissue Engineering ($ 2,000,000, PI)
2008-2009 Coulter Translational Research Foundation ($ 100,000, PI)
2008-2011 National Science Foundation Smart Screw Manufacturing ($ 650,000 CoPI)
2008-2010 Craig H. Neilsen Foundation Spinal Cord Tissue Engineering ($ 250,000 PI)
2008-2012 PATRIC (Pennsylvania Advanced Textile Research and InnovationCenter ($ 1,200,000, CoPI)
March 28, 2009
LIST OF PUBLICATIONS
Peer-Reviewed Articles

1. Zimmermann, U., Steudle, E., and Lelkes, P.I. (1976) Turgor pressure regulation in Valonia utricularis: effect of cell wall elasticity and auxin. Plant Physiol 58:608-613.
2. Lelkes, P.I., Kapitkovsky, A., Eibl, H., and Miller, I.R. (1979) Headgroup dependent modulation of phase transition in dipalmitoyllecithin analogs. FEBS Lett 103:101-105.
3. Lelkes, P.I. (1979) Potential dependent rigidity changes in lipid membrane vesicles. Biochem Biophys Res Commun 90:656-662.
4. Lelkes, P.I., and Miller, I.R. (1980) Perturbations of membrane structure by optical probes. I. Location and structural sensitivity of Merocyanine 540 bound to phospholipid membranes. J Membr Biol 52:1-15.
5. Lelkes, P.I., Bach, D., and Miller, I.R. (1980) Perturbations of membrane structure by optical probes. II. Differential scanning calorimetry of dipalmitoyl-lecithin and its analogs interacting with Merocyanine 540. J Membr Biol 54:141-148.
6. Lelkes, P.I., Lavie, E., Naquira, D., Schneeweiss, F., Schneider, A., and Rosenheck, E. (1980) Acetylcholine induced in vitro fusion between cell membrane vesicles and chromaffin granules from the bovine adrenal medulla. FEBS Lett 115:129-133.
7. Friedman, J.E., Lelkes, P.I., Rosenheck, K., and Oplatka, A. (1980) The possible implication of membrane-associated actin in stimulation-secretion coupling in adrenal chromaffin cells. Biochem Biophys Res Commun 96:1717-1723.
8. Yatvin, M. B., and Lelkes, P.I., (1982) Clinical prospects for liposomes. Med Phys 9:149-175
9. Lelkes, P.I., and Tandeter, H.B., (1982) Studies on the methodology of the carboxyfluorescein assay and on the mechanism of liposome stabilization by red blood cells in vitro. Biochim Biophys Acta 716:410-419.
10. Gurari-Rotman, D., and Lelkes, P.I. (1982) Encapsulation of human fibroblast interferon activity into liposomes. Biochem Biophys Res Commun 107:1363.
11. Lelkes, P.I., Goldenberg, D., Gliozzi, A., DeRosa, M., and Miller, I.R. (1983) Vesicles from mixtures of bipolar archaebacterial lipid with egg phosphatidylcholine. Biochim Biophys Acta 732:714-718.
12. Lelkes, P.I., Klein, L., Marikovsky, J., and Eisenbach, M. (1984) Liposome mediated transfer of macromolecules into flagellated cell envelopes from bacteria. Biochemistry 23:563-568.
13. Bental, M., Lelkes, P.I., Scholma, J., Hoekstra, D., and Wilschut, J. (1984) Ca++ independent, protein-mediated fusion of chromaffin granule ghosts with liposomes. Biochim Biophys Acta 774:296-300.
14. Lelkes, P.I., and Friedmann, P. (1984) Stabilization of large multimellar liposomes by human serum in vitro. Biochim Biophys Acta 775:395-401.
15. Lelkes, P.I., and Friedman, J.E. (1985) Interactions of French-pressed liposomes with isolated bovine adrenal chromaffin cells. I. Characterization of the cell-liposome interactions. J Biol Chem 260:1796-1803.
16. Friedman, J.E., Lelkes, P.I., Lavie, E., Rosenheck, K., Schneeweiss, F., and Schneider, A.S. (1985) Membrane potential and catecholamine secretion by bovine adrenal chromaffin cells: Use of tetraphenyl phosphonium distribution and carboxycyanine dye fluorescence. J Neurochem 44: 1391-1402.
17. Lelkes, P.I., Friedman, J.E., and Rosenheck, K. (1985) Direct fluorometric assay of catecholamine secretion form isolated bovine adrenal chromaffin cells. J Neurosci Meth 13:249-255.
18. Braun, G., Lelkes, P.I., and Nir, S.( 1985) Effect of cholesterol on Ca++-induced aggregation on fusion of sonicated phosphatidylserine/cholesterol vesicles. Biochim Biophys Acta 812:688-694.
19. Pollard, H.B., Ornberg, R., Levine, M., Brocklehurst, K., Forsberg, E., Lelkes, Peter, I., and Morita, K. (1985) Regulation of secretion from adrenal chromaffin cells. Physiologist 28:247 254.
20. Friedman, J.E., Lelkes, P.I., Rosenheck, K., and Oplatka, A. (1986) Control of stimulus-secretion coupling in adrenal medullary chromaffin cells by microfilament specific macromolecules. J Biol Chem 261:5745-5750.
21. Sömjen, G., Marikovsky, Y., Lelkes, P.I., and Gilat, T. (1986) Cholesterol-phospholipid vesicles in human bile: an ultrastructural study. Biochim Biophys Acta 879:14-21.

22. Lelkes, P.I., Friedman, J.E., Rosenheck, K., and Oplatka A. (1986) Destabilization of actin filaments as a requirement for the secretion of catecholamines from permeabilized chromaffin cells. FEBS Lett, 308:375-383.
23. Duling, B.R., Hogan, R., Langielle, R., Lelkes, P.I., Segal, S., Vatner, S., and Weigelt, H. (1987) Vasomotor control: functional hyperemia and beyond. Federation Proc 46:251-263.
24. Lelkes, P.I., and Pollard, H.B. (1987) Oligopeptide Inhibitors of metalloendoprotease activity inhibit catecholamine secretion from bovine adrenal chromaffin cells by modulating intracellular calcium homeostasis. J Biol Chem 262:15496-15505.
25. Stutzin, A., Cabantchik, Y., Lelkes, P.I., and Pollard, H.B. (1987) Synexin-mediated fusion of bovine chromaffin granule ghosts. Effect of pH. Biochim Biophys Acta 905:205-212.
26. Megnin, F., Faustino, P.J., Lyon, R.C., Lelkes, P.I., and Cohen, J.S. (1987) On the mechanism of selective retention of porphyrins and metalloporphyrins by cancer cells. Biochim Biophys Acta 929:173-181.
27. Lelkes, P.I., and Lazarovici, P. (1988) Pardaxin induces aggregation but not fusion of phosphatidylserine vesicles. FEBS Lett 230:131-136.
28. Mizrachi, Y., Lelkes, P.I., Ornberg, R., and Pollard, H.B. (1989) Specific interactions between PC12 cells and adrenomedullary endothelial cells in co-culture. Cell Tissue Res 256:365-372.
29. Lazarovici, P., Levi, B-Z., Lelkes, P.I., Koizumi, S., Fujita, K., Matsuda, Y., Ozato, K., and Guroff, G. (1989) K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells. J Neurosci Res 23:1-8.
30. Lazarovici, P., Fujita, K., Contreras, M.L., DiOrio, J.P., and Lelkes, P.I. (1989) Affinity-purified tetanus toxin binds to isolated chromaffin granules and inhibits catecholamine release in digitonin permeabilized chromaffin cells. FEBS Lett 253: 121-128.
31. Fink, D., Contreras, M.L., Lelkes, P.I., and Lazarovici, P. (1989) Staphylococcus aureus -toxin activates phospholipases and induces a Ca2+ influx in PC12 cells Cell Signal 1:387-393.
32. Criscuolo, G.R., Lelkes, P.I., Rotrosen, D., and Oldfield, E.H. (1989) Cytosolic calcium changes in cultured endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity. J Neurosurg 71:884-891.
33. Mizrachi, Y., Naranjo, J.R., Pollard, H.B., and Lelkes, P.I., (1990) PC12 Cells differentiate into chromaffin cell like phenotype in co-culture with adrenal medullary endothelial cells, Proc Natl Acad Sci USA 87:6161-6185.
34. Brandi, M.L., Ornberg, R.L., Sakaguchi, K., Curcio, F., Fattorossi, A., Lelkes, P.I., Matsui, T., Zimering, M., and Aurbach, G.D. (1990) Establishment and characterization of a clonal line of parathyroid endothelial cells. FASEB J 4:3152-3158.
35. Lelkes, P.I. (1991) New aspects of endothelial cell biology. J Cell Biochem 45:242-244.
36. Lelkes, P.I., and Samet, M. (1991) Endothelialization of the luminal sac in artificial cardiac prostheses: A challenge for both biologists and engineers. J Biomech Eng 113:132-142.
37. Grant, D.S., Lelkes, P.I., Fukuda, K., and Kleinman, H.K. (1991) Intracellular mechanisms involved in basement membrane induced blood vessel differentiation in vitro, In Vitro Cell Dev Biol 27A:327-336.
38. Lelkes, P.I., and Samet, M.M. (1991) Analysis of pulsatile flow and EC morphology in VAD-like cell culture chambers. ASAIO Trans 37: M1315-M1316.
39. Yuli, I., and Lelkes, P.I. (1991) Evaluation of an exoplasmic neutral endopeptidase activity in the interaction of human polymorphonuclear leukocytes with the chemoattractant N-formyl-L-methionyl-L-leucyl-L-phenylalanine, Eur J Biochem 177: 1-10.
40. Lazarovici, P., and Lelkes, P.I. (1992) Pardaxin evokes exocytotic catecholamine and ATP release from chromaffin cells independent of intracellular calcium, J Pharmacol Exp Ther 263:1317-1326.
41. Christensen, C.W, Samet, M.M., Chick, D.M., and Lelkes, P.I. (1992) Experimental studies of pulsatile flow and endothelial-cell adaptation in ventricle-shaped cell culture chambers, ASAIO J 38(3):M501-M506.
42. Samet, M.M., Christensen, C.W., Chick, D.M., and Lelkes, P.I. (1992) The importance of flow visualization for successful endothelialization of artificial ventricles, Wisc Prof Eng 11/12:14-16.
43. Papadimitriou, E., and Lelkes, P.I. (1993) Measurement of cell numbers in microtiter culture plates using the fluorescent dye Hoechst 33258. J Immunol Methods 162:41-45.
44. Manolopoulos, V.G., and Lelkes, P.I. (1993) Cyclic strain and forskolin differentially induce cAMP production in phenotypically diverse endothelial cells. Biochem Biophys Res Commun, 191:1379-1385.
45. Wilke, R.A., Riley, D.A., Lelkes, P.I., and Hillard, C.J. (1993) Decreased catecholamine secretion from the adrenal medullae of chronically diabetic BB-Wistar rats. Diabetes, 42:862-868.
46. Samet, M.M., Chick, D.M., Christensen, C.W., and Lelkes, P.I. (1993) Morphology and integrity of endothelial cell monolayers inside a ventricle-shaped perfusion chamber. ASAIO J, 39:M403-M409.
47. Papadimitriou, E., Unsworth, B.R., Maragoudakis, M.E., and Lelkes, P.I. (1993) Time course and quantitation of extracellular matrix maturation in the chick chorioallantoic membrane and in cultured endothelial cells. Endothelium, 1:207-219.
48. Lelkes, P.I. (1993) Conference Report: Endothelial Cell Heterogeneity and Organ-Specificity, Endothelium, 1:69-70.
49. Lin, H.B., Sun, W., Mosher, D.F., Garcia-Echeverria, C., Schaufelberger, K., Lelkes, P.I., and Cooper, S.I. (1994) Synthesis, surface, and cell-adhesion properties of polyurethanes containing covalently grafted RGD-peptides. J Biomed Mater Res, 28: 329-342.
50. Lelkes, P.I., Gao, H., Edgerton, J.R., and Christensen, C.W. (1994) Endothelial cell seeding of latissimus dorsi muscle pouches. J Surg Res, 57:460-469.
51. Lelkes, P.I. (1994) Cytotoxicity of carbobenzoxy-protected amino acids, Letter to the editor. In Vitro Cell Dev Biol, 30A:75-76.
52. Samet, M.M., and Lelkes, P.I. (1994) Pulsatile flow and endothelial cell morphology in a cell culture chamber model of an artificial cardiac ventricle. J Biomech Eng, 116:369-371.
53. Samet, M.M., and Lelkes, P.I. (1994) Flow patterns and endothelial cell morphology in a simplified model of an artificial ventricle. Cell Biophys and Bioeng, 23:139-163
54. Haralabopoulos, G.C., Grant, D.S. Kleinman, H.K., Lelkes, P.I., Papaioannou, S.P., and Maragoudakis, M.E. (1994) Inhibitors of basement membrane collagen biosynthesis prevent endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo, Lab Investigations, 71:575-582.
55. Lelkes, P.I. (1994) Conference Report: Endothelial Cell Heterogeneity and Organ-Specificity, Endothelium, 2:139-141.
56. Nikolaychik, V.V., Samet, M.M., and Lelkes, P.I. (1994) A new, cryoprecipitate based coating for improved endothelial cell attachment and growth on medical grade artificial surfaces. ASAIO J, 40:M846-M852.
57. Samet, M.M., Wankowski, D.M., Nikolaychik, V., and Lelkes, P.I. (1994) Endothelial cell seeding with rotation of a ventricular blood sac. ASAIO J, 40:M319-M324.
58. Lelkes, P.I., Ramos, E., Chick, D.M., Liu, J., and Unsworth, B.R. (1994) Microgravity decreases tyrosine hydroxylase expression in rat adrenals. FASEB J, 8:1177-1182.
59. Manolopoulos, V.G., Liu, J., Unsworth, B.R. and Lelkes, P.I. (1995) Adenylyl cyclase isoforms are differentially expressed in primary cultures of endothelial cells and whole tissue homogenates from various rat issues Biochem Biophys Res Commun, 208:323-331
60. Thomas, G.A., Lelkes, P.I., Chick, D.M., Isoda, S., Lu, H., Nakajima, H., Hammond, R.L., Nakajima, H., Walters, H.L. III, and Stephenson, L.W. (1995) Skeletal muscle ventricles seeded with autogenous endothelium. ASAIO J, 41:204-211.
61. Thomas, G.A., Lelkes, P.I., Isoda, S., Chick, D., Lu, H., Hammond, R.L., Nakajima, H., Walters, H.L.III, and Stephenson, L.W. (1995) Endothelial cell-lined skeletal muscle ventricles in circulation, J Thorac Cardiovasc Surg., 109:66-73.
62. Manolopoulos, V.G., Samet, M.M., and Lelkes, P.I.(1995) Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cells. J Cell Biochem, 57:590-598.
63. Samad, F., Bergtrom, G., Lelkes, P.I., and Amrani, D.L. (1995) Differential cytokine regulation of PAI-1 gene expression between human umbilical and subcutaneous fat-derived microvascular endothelial cells, Endothelium, 3:243-252.

64. Thomas, G.A., Lelkes, P.I., Chick, D.M., Lu, H., Kowal, T.A., Hammond, R.L., Nakajima, H., and Stephenson, L.W. (1995) Endothelial lined skeletal muscle ventricles: Open and percutaneous techniques. J. Card Surg, 10:245-256.
65. Silverman, M., Manolopoulos, V.G., Unsworth B.R., and Lelkes, P.I. (1996) Tissue factor expression is differentially modulated by cyclic mechanical strain in various human endothelial cells, Blood Coagulation and Fibrinolysis, 7:281-288.
66. Nikolaychik, V.N., Samet, M.M., and Lelkes, P.I. (1996) A new method for continual quantitation of viable cells on endothelialized polyurethanes, J. Biomat. Sci, 7:881-891.
67. Nikolaychik, V.V., Wankowski, D.M., Samet, M.M., Lelkes, P.I. (1996) In Vitro testing of endothelial cell monolayers under dynamic conditions inside a beating ventricular prothesis. ASAIO J., 42: 487-494.
68. Rasouly, D., Shavit, D., Zuniga, R., Elejalde, R. B., Unsworth, B.R., Yayon, A., Lazarovici, P.,and Lelkes, P.I. (1996) Staurosporine induces neurite outgrowth in neuronal hybrids (PC12EN) lacking NGF receptors. J Cell Biochem, 61:1-16.
69. Chekanov, V.S., Tchekanov, G.V., Rieder, M.A., Eisenstein, R., Wankowski, D.M., Schmidt, D.H., Nikolaychik, V.V., Lelkes, P.I. (1996) Biological glue increased capillary ingrowth after cardiomyoplasty in an ischemic cardiomyopathy model, ASAIO J, 42:480-487.
70. Garcia, R.M.G., Atwater, I., Lelkes, P.I., and Mathias, P.C.F. (1996) The inhibition of K+-secretory response by caffeine in bovine chromaffin cells is time dependent. Res. Comm. Alcohol and Subst. Abuse, 17: 15-21.
71. Papadimitriou, E., Manolopoulos, V.G., Hayman, G.T., Maragoudakis, M.E., Unsworth, B.R, Fenton II, J.W., and Lelkes, P.I. (1997) Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells. Am J Physiol, 272: C1112-C1122.
72. Jiang, H., Movsesyan, V., Fink, D.W. Jr., Fasler, M., Whalin, M., Katagiri, Y., Monshipouri, M., Dickens, G., Lelkes, P.I., Guroff, G., and Lazarovici, P. (1997) Expression of Human trkA Receptors in trkA-deficient, PC12/Endothelial Cells Results in Nerve Growth Factor-induced Signal Transduction and DNA Synthesis. J Cell Biochem, 66:229-244
73. Manolopoulos, V.G., Fenton II, J.W., and Lelkes, P.I. (1997) The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein. Biochim. Biophys. Acta, 1356:321-332.
74. Lelkes, P.I., Ramos, E.M., Nikolaychik, V., Unsworth, B.R., and Goodwin, T. (1997) GTSF: a new, versatile cell culture medium for diverse normal and transformed mammalian cells, In Vitro Cell Dev Biol 33:344-351.
75. Lelkes, P.I., Galvan, D.L., Hayman, G.T., Goodwin, T.J., Chatman, D.Y., Cherian, S., Garcia, R.M.G., and Unsworth, B.R. (1998) Simulated microgravity conditions enhance differentiation of cultured PC12 cells towards the neuroendocrine phenotype. In Vitro Cell Dev Biol, 34:316-325.
76. Chekanov, V.S., Nikolaychik, V.V., Rieder, M.a., Tchekanov, G.V., Hernandez, I., Eisenstein, R.,Francischelli, D., Lelkes, P.I., and Schmidt, D.H. (1998) Autologous biological glue and aprotinin prevent latissiumus dorsi muscle postmobilization ischemia. Basic and Applied Myology 8:211-219.
77. Unsworth. B.R. and Lelkes,. P.I. (1998) Growing Tissues in Microgravity. Nature Medicine, 4:901-908.
78. Kanda, K., Hayman, G.T., Silverman, M.D., and Lelkes, P.I. (1998) Comparison of ICAM-1 and VCAM-1 expression in various human endothelial cell types and smooth muscle cells. Endothelium, 6:33-44.
79. Nikolachik, V.V. Ferguson, J.J. Lelkes, P.I., Horn, J., and Kipshidze, N. (1998) Fibrin meshwork sealing after artery catheterization: optimization and mechanisms. Int J. Cardiovasc. Med. Sci. 1:191-198.
80. Lelkes, P.I., Hahn, K.A., Sukovich, D.A., Karmiol, S., and Schmidt, D.H. (1998) On the possible role of reactive oxygen species in angiogenesis. Adv Exp Med Biol, 454:295-310.
81. Lelkes, P.I. and Unsworth, B.R. (1998) Cellular signaling mechanisms involved in the 3-dimensional assembly and differentiation of PC12 pheochromocytoma cells under simulated microgravity in NASA rotating wall vessel bioreactors, J Amer Soc Mech Eng, Adv. Heat and Mass Transfer, 362:35-41.
82. Lelkes, P.I., Kettlun, C.S., Waters, C.R., Wigboldus, J., Sukovich, D.A., and Rubanyi, G.M. (1998) Signaling mechanisms involved in endothelial cell activation by perturbed flow, 5th Internet World Congress for Biomedical Sciences(INABIS98) URL:http://www.mcmaster.ca/inabis98/nilius/lelkes0243/index.html
83. Henry, M.K., Unsworth, B.R., Sychev, V., Guryeva, T.S., Dadasheva, O., Piert, S.J., Lagel, K.E., Dubrovin, L.C., Jahns, G.C., Boda, K., Sabo V. Samet, M.M., and Lelkes, P.I. (1998) Launch conditions might affect the formation of blood vessels in the quail chorioallantoic membrane. Folia Vet. 42: S25-31.
84. Abu-Raya, S., Bloch-Schilderman, E., Lelkes, P.I., Trembovler, V., Shohami, E., Gutman, Y., and Lazarovici, P. (1999) Characterization of pardaxin-induced dopamine release from pheochromocytoma cells: Role of calcium and eicosanoids. J Pharmacol Exp Ther, 288:399-406.
85. Kuehn, R., Lelkes, P.I., Bloechle, C., Niendorf, A., and Izbicki, J.R., (1999) Angiogenesis, angiogenic growth factors and cell adhesion molecules are upregulated in chronic pancreatic diseases: Angiogenesis in chronic pancreatitis and pancreatic cancer. Pancreas, 18:96-103.
86. Unsworth, B.R., Hayman, G.T., and Lelkes, P.I. (1999) Tissue-specific alternative mRNA splicing of phenolethanolamine-N-methyl tranferase (PNMT) during development by intron retention, Int J Develop Neurosci, 17:45-55.
87. Silverman, M.D. Hayman, G.T., Waters, C.R., Wigboldus J., Samet, M.M., and Lelkes, P.I. (1999) Tissue factor activity is increased in human endothelial cells cultured under elevated static pressure. Am J Physiol. 277: C233-C242.
88. Lelkes, P.I., Brooks, A. Sukovich, D. and Rubanyi, G.,M. (2000) Activation of Cultured Human Endothelial Cells Exposed to Perturbed Pulsatile Flow. 6th Internet World Congress for Biomedical Sciences(INABIS2000), http://www.uclm.es/inabis2000/symposia/files/184/index.htm
89. Nikolaychik VV, Chekanov VS, Hernandez I, Silverman MD, Lelkes PI. (2000) Biodesign of a skeletal muscle flap as a model for cardiac assistance. Artif Organs. 24:137-147.
90. Manolopoulos VG, Liekens S, Koolwijk P, Voets T, Peters E, Droogmans G, Lelkes PI, DeClercq E, and Nilius B. (2000) Inhibition of angiogenesis by blockers of volume-regulated anion channels. Gen Pharmacol. 34:107-116.
91. Lelkes, E., Unsworth, B.R. and Lelkes, P.I. (2001) Reactive oxygen species, apoptosis and altered NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose: an in vitro cellular model for diabetic neuropathy. Neurotoxicity Res. 3:189-203.
92. Burnatowska-Hledin, M., Zeneberg, A., Roulo, A., Grobe, J., Lelkes, P.I., Clare, P., and Barney, C. (2001) Expression of VAMC-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. Endothelium 8:49-63.
93. Lelkes, P.I. Akhtar, N. Lelkes, E. Maltz, L. Arthur, R. Wiederholt, J. and Unsworth, B.R (2001) Neuroendocrine tissue engineering in rotating wall vessel bioreactors under simulated microgravity conditions. Proc. 23rd Annual International Conference of the IEEE, 3: 2987- 2990.
94. Papadimitriou, E., Waters, C.R., Manolopoulos, V.G., Maragoudakis, M.E., Unsworth, B.R., and Lelkes, P.I. (2001) Regulation of Extracellular Matrix Deposition and MMP-2 Activation in Cultured Rat Adrenal Medullary Endothelial Cells. Endothelium, 8:243-53.
95. Lelkes P.I., Akhtar, N., Maltz, L., Lelkes, E., Arthur, R., Wiederholt, J., and Unsworth, B.R., (2002) Vascularization of functional neuroendocrine tissue constructs generated in rotating wall vessel bioreactors Endothelium 9: 65-66.
96. Silverman, M.D., Tumuluri, R.J., Davis, M., Lopez, G., J.T. Rosenbaum and Lelkes, P.I. (2002) Homocysteine upregulates vascular cell adhesion molecule-1 expression in cultured human aortic endothelial cells and enhances monocyte adhesion. Arteriosclerosis, Thrombosis Vascular Biology, 22:587-592.
97. Brooks, A.R., Lelkes, P.I., Bartholdi, M., and Rubanyi , G.M. (2002) Gene Expression Profiling of Human Aortic Endothelial Cells Exposed to Disturbed Flow and Steady Laminar Flow , Physiological Genomics, 9:27-41.
98. Guterman, E. Cheng, S., Palouian, K., Bidez, P.R., Lelkes, P.I., and Wei, Y. (2003) Peptide-modified electroactive polymers for tissue engineering applications, Polym. Prepr. Am. Chem. Soc., Div. Polym. Chem. 43:766-767
99. Rezvan A. Allen, F.D. and Lelkes , P.I. (2004) Steady Unidirectional, Laminar Flow Inhibits Monolayer Formation by Human and Rat Microvascular Endothelial Cells. Endothelium. 11:11-16.
100. Brooks A. R., Lelkes, P. I., and Rubanyi, G.M. (2004) Gene Expression Profiling of Vascular Endothelial Cells Exposed to Fluid Mechanical Forces: Relevance for Focal Susceptibility to Atherosclerosis, Endothelium, 11:45-57.
101. Martins, A.C., Souza, K.L., Shio, M.T., Mathias, P.C., Lelkes, P.I., and Garcia RM. (2004) Adrenal medullary function and expression of catecholamine-synthesizing enzymes in mice with hypothalamic obesity. Life Sci. 74:3211-3222.
102. Guo, Y., Wei, Y., Lelkes, P.I., Ko, F.K, Li, S., and Feng, Q. (2005) Synthesis and characterization of novel electroactive aniline trimer-containing organosilane materials, Polym. Mater. Sci. Eng., 92:320-321.
103. Li, M., Mondrinos, M.J., Yang, Y., Gandhi, M.R., Ko, F.K., Yang, G., Weiss, A.S., and Lelkes, P.I. (2005) Electrospun Protein Fibers as Matrices for Tissue Engineering, Biomaterials, 26:5999-6008.

104. Gregory Fridman, G., Li, M., Lelkes P.I., Friedman, G., Fridman, A., and Gutsol, A. (2005) Non-Thermal Plasma Bio-Active Liquid Micro and Nano-Xerography" , IEEE Transactions on Plasma Science 33: 1061-1065.
105. Lu, L., Mondrinos, M.J., Lelkes, P.I., Wootton, D., and Zhou, J. (2005) Manufacturing System Development for Fabrication of Bone Scaffold, Proc ASME International Mechanical Engineering Congress, in press
106. Li, M., Mondrinos, M.J. , Chen, X., and Lelkes, P.I. (2005) Electrospun Blends of Natural and Synthetic Polymers as Scaffolds for Tissue Engineering, IEEE-BMES Transactions, 27: 5858 – 5861.
107. Uttayarat, P.., Toworfe, G.K., Lelkes, P.I., and Composto, R., (2005) Nano- to micro- scale topographic guidance for the orientation and the cytoskeletal protein alignment of cultured bovine aortic endothelial cells on textured silicone surfaces, Journal of Biomedical Materials Research: Part A, 75:668-680.
108. Wei, Y., Yin, H., Cao, X., Ndungu, P., Bradley, J., Yang, G., Pourrezaei, K., Lelkes, P.I., and Tsien, J. Z. (2005) Nanoelectrodes Fabricated from Electron Beam Deposited Carbon as Potential Electrochemical Neuronal Probes, Journal of Biomedical Nanotechnology, 1: 336-340.
109. Bidez, P.R., Wei, Y., MacDiarmid, A.G., and Lelkes, P.I. (2006) Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts, Journal of Biomaterials Science. Polymer Edition, 17: 199-212.
110. Mondrinos, M.J, Koutzaki, S., Jiwanmall, E., Li., M. DeChadaverian, J.P.,Lelkes, P.I. and Finck, C.M. (2005) Engineering 3-D Pulmonary Tissue Constructs, Tissue Engineering, 12: 717-726.
111. Huang, L., Hu, J., Zhuang, X., Ma, J., Chen, X., Jing, X., Guo, Y., Li, M., Lelkes, P.I., and Wei, Y. (2005). Synthesis and characterization of electro-active and biodegradable block copolymer of aniline pentamer with polylactide, Chemical Journal of Chinese Universities, 26: 1171-1173.
112. Dolle, J.P. Rezvan, A., Fred D. Allen, F.D., Lazarovici, P., and Lelkes, P.I. (2005) Nerve Growth Factor Induced Migration of Endothelial Cells, Journal of Pharmacology and Experimental Therapeutics, 315:1220-1227.
113. Darling, A., Shor, L., Khalil, S., Mondrinos, M., Lelkes, P., Guceri, S. and Sun, W. (2005) “Multi-materials scaffolds for tissue engineering”, Macromolecular Symposia, 227: 345-356.
114. Ritz, B.W., Lelkes, P.I., and Gardner, E.M. (2006) Functional recovery of peripheral blood mononuclear cells in modeled microgravity, FASEB J., 20:305-307.
115. Simons, D.M., Gardner, E.M., and Lelkes, P.I. (2006) Dynamic Culture in a Rotating-Wall Vessel Bioreactor Inhibits Murine T-Lymphocyte Activation Upon Return to Static Conditions in a Time-Dependent Manner J Appl Physiol. 100:1287-1292.
116. Li, M., Guo, Y., Wei, Y., MacDiarmid, A.G., and Lelkes, P.I. (2006) Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. Biomaterials. 27:2705-2715.
117. Lazarovici, P., Marcinkiewicz, C., and Lelkes, P.I (2006), Cross Talk between the Cardiovascular and Nervous Systems: Neurotrophic Effects of Vascular Endothelial Growth Factor (VEGF) and Angiogenic Effects of Nerve Growth Factor (NGF)-Implications in Drug Development. Current Pharmaceutical Design, 12:2609-2622.
118. Li, M., Mondrinos, M.J., Gandhi, M.R., Ko, F.K. Chen, X., and Lelkes, Peter I. (2006) Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds. J Biomed Mater Res A. 79:963-73.
119. Manley, P. and Lelkes, P.I. (2006) A Novel Real-time System to Monitor Cell Aggregation and Trajectories in Rotating Wall Vessel Bioreactors, J Biotechnol. 125:416-424.
120. Dietrich F., and Lelkes, P.I. (2006) The three-dimensional microcarrier-based angiogenesis assay and its application for co-culture studies, Angiogenesis, 9:111-125.
121. Mondrinos, M.J. Dembzynski, R., Lu, L., Byrapogu, V.K.C., Wootton, D.M. Lelkes, P.I, and Zhou, J. (2006) Porogen-based Solid Freeform Fabrication of Polycaprolactone-Calcium Phosphate Scaffolds for Tissue Engineering, Biomaterials, Biomaterials. 27:4399-4408.
122. Lazarovici, P., Gazit, A., Staniszewska, I., Marcinkiewicz, C., and Lelkes, P.I. (2006) Nerve Growth Factor Promotes Angiogenesis in the Quail Chorioallantoic Membrane. Endothelium. 13:51-59.
123. Vamvakidou, A.P., Mondrinos, M.J., Petushi, S.P., Garcia, F.U., Lelkes, P.I., and Tozeren A. (2006) Heterogeneous Breast Tumoroids: An In Vitro Assay for Investigating Cellular Heterogeneity and Drug Delivery. J Biomol Screen. 12:13-20.
124. Li, M., Bidez, P., Guterman-Tretter, E., Gou, Y., MacDiarmid, A.G., Lelkes, P.I., Yuan, X.B., Yuan X.Y., Sheng, J., Li, H., Song, C.X., and Wei, Y. (2006) Research Progress on Electroactive and Electrically Conductive Polymers for Tissue Engineering Scaffolds Acta Acad Med Sin 28: 845-848.
125. Huang, L., Hu, J., Lang, L., Wang, X., Zhang, P., Jing, X., Wang, X., Chen, X., Lelkes. P.I., MacDiarmid, A.G., and Wei Y. (2007) Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer. Biomaterials. 28:1741-1751.
126. Botta, G.P., Manley, M., Miller, S., and Lelkes, P.I. (2007) Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro, Nature Protocols, 1: 2116-2126.
127. Mondrinos, M.J., Koutzaki, S., Lelkes, P.I., and Finck, C.M. (2007) A tissue-engineered model of fetal distal lung tissue. Am J Physiol Lung Cell Mol Physiol. 293:L639-650.
128. Crisanti, C.M., Koutzaki, S.H., Mondrinos, M.J., Lelkes, P.I., and Finck, C.M.(2007) Novel Methods for Delivery of Cell-Based Therapies. J Surg Res. 2007 Jul 25; [Epub ahead of print]
129. Guo, Y., Li, M., Mylonakis, A., Han, J.G., Macdiarmid, A., Chen, X., Lelkes, P.I., and Wei, Y. (2007) Electroactive Oligoaniline-Containing Self-Assembled Monolayers for Tissue Engineering Applications. Biomacromolecules. 8:3025-3034.
130. Moxon KA, Hallman S, Aslani A, Kalkhoran NM, Lelkes PI. (2007) Bioactive properties of nanostructured porous silicon for enhancing electrode to neuron interfaces. J Biomater Sci Polym Ed. 2007;18(10):1263-81.
131. Mondrinos MJ, Koutzaki SH, Poblete HM, Crisanti MC, Lelkes PI, Finck CM. (2007) In Vivo Pulmonary Tissue Engineering: Contribution of Donor-Derived Endothelial Cells to Construct Vascularization Tissue Eng. 2007 Nov 5; [Epub ahead of print]
132. Uttayarat, P., Chen, M., Li M, Allen, F.D., Composto, R.J., and Lelkes, P.I. (2007) Microtopography and Flow Modulate the Direction of Endothelial Cell Migration. Am J Physiol Heart Circ Physiol. 2007 Dec 21; [Epub ahead of print]
133. Zhou, J., Lu, L., Byrapogu, K., Wootton, D.M., Lelkes, P. I., and Fair, R. (2007) Electrowetting-based multimicro- fluidics array printing of high resolution tissue construct with embedded cells and growth factors, Virtual and Physical Prototyping 2:217 – 223.
134. Li, M., Bidez, P., Guterman-Tretter, E., Yi Guo, Y., G. MacDiarmid, A. G., Lelkes P.I.,* Yuan, X.-B., Yuan, X.-Y. Sheng, J., Li, H., Song, C., and Wei*, Y. (2007) Electroactive and nanostructured polymers as scaffold materials for neuronal and cardiac tissue engineering, Chinese Journal of Polymer Science (English edition), accepted for publication, 2007.
135. Guo, Y., Mylonakis, A., Zhang, Z., Yang, G., Lelkes. P.I., Che, S., Lu, Q., and Wei, Y. (2008) Templated Synthesis of Electroactive Periodic Mesoporous Organosilica Bridged with Oligoaniline. Chemistry. Jan 25; [Epub ahead of print]
136. Vishal Kamat, Joshua M. Donaldson, Csaba Kari, Marlene R.D. Quadros, Peter I. Lelkes, Irwin Chaiken, Simon Cocklin, John C. Williams, Elisabeth Papazoglou and Ulrich Rodeck (2008) Enhanced EGFR Inhibition and Distinct Epitope Recognition by EGFR Antagonistic Mabs C225 and 425. Cancer Biology & Therapy, in press (April 2008)
137. Arien-Zakay, H., Lecht, S., Perets, A., Roszell, B., Lelkes, P.I, and Lazarovici, P. (2008) Quantitative assessment of neuronal differentiation in three dimensional collagen gels, using enhanced Green Fluorescence Protein expressing - PC12 pheochromocytoma cells, J. Molec. Neurosci., in press
138. Ringel I, Lecht S, Sterin M, Lelkes P.I and Lazarovici P. (2009) 31P Magnetic Resonance Spectroscopy of Endothelial Cells Grown in 3D Matrigel Construct as an Enabling Platform Technology: I. The Effect of Glial Cells and Valproic Acid on Phosphometabolites Level, Endothelium, in press
139. Ringel I, Lecht S, Sterin M, Lelkes P.I and Lazarovici P. (2009) 31P Magnetic Resonance Spectroscopy of Endothelial Cells Grown in 3D Matrigel Construct as an Enabling Platform Technology II: The Effect of Anti-Inflammatory Drugs on Phosphometabolites Level,, Endothelium, in press
140. Roszell, B., Mondrinos, M.J., Seaton, A., Simons, D.M., Koutzaki, S.H.,. Fong, G.H., Finck, C.M., and Lelkes, P.I. (2009) Differentiation of Embryonic Stem Cells to Definitive Endoderm and Alveolar Epithelial Type II Cells, Tissue Engineering, in press
141. Mondrinos, M.J., Finck, C.M., Chen, X., and Lelkes , P.I. (2009) Optimization of Cell Seeding in Tissue Engineered Scaffolds, manuscript under reversion
142. Mondrinos, M.J., Koharski C. D, Bidez P. R., and Lelkes, P.I. (2009) Decellularized Murine Myocardium as a Tissue-Specific Scaffold for Cardiac Tissue Engineering, Biomaterials, manuscript under revision.
143. Zhang, X., Wang, C., Zhao, Y. Yang, L., Guo, X., Jiang, H., E, L., Li, J., Duan, C., Dong, L., Bidez, P. R., and Lelkes, P. I. (2009) Large Scale Production of Embryoid Bodies in Rotating Wall Vessel Bioreactor Culture, manuscript submitted for publication
144. Hong, J., Kong Q., Ma, H., Wang, C., Duan, C. Li, H., Wu, J. Guo, X., Lelkes, P.I., and Song, Y. (2009) Sertoli-Islet Cell Aggregates Generated in Rotating Wall Vessel Bioreactors: Prolonged Survival in Diabetic Rats in the Absence of Systemic Immunosuppression, Diabetes, manuscript submitted for publication
145. Lelkes, P.I (2009) Differential Activation of Endothelial Cells by Distinct Hemodynamic Forces. Endothelium, manuscript submitted for publication.
146. Lelkes, P.I, Akthar, N., Auerbach R., Lelkes E., and Unsworth, B.R. (2009) Generation of Functional Neuroendocrine Tissues in Rotating Wall Vessel Bioreactors , manuscript submitted for publication
147. Kang, S., Bidez, P.R. and Lelkes , P.I.(2009) Characterization of Carbon-Nanotube Doped Collagen Scaffolds For Tissue Engineering Applications, manuscript submitted for publication
148. Lelkes, P.I., Samet, M.M., Davis, M., Sukovich, M., Brooks, A., Wigboldus, J., Waters, C., Rubanyi, G.M. (2009), Upregulation of VCAM-1 Expression in Cultured Human Endothelial Cells Exposed to Perturbed Pulsatile Flow. Manuscript submitted for publication
149. Guo, Y., Mylonakis, A., Wei, Y., P. I. Lelkes, P.I., *Ko, F.K., Li, S., and Feng, Q. (2009) Aniline-contained Electroactive silsesquioxane precursor for synthesizing novel siliceous materials, manuscript submitted for publication
150. Li, M., Perets, A., and Lelkes, P.I., (2009) Nanofiber Scaffolds for Tissue Engineering. Journal of Biomaterials Science (JBS) – Polymer Edition, manuscript submitted for publication




BOOKS, BOOK CHAPTERS
1. Steudle, E., Lelkes, P.I., and Zimmermann, U. (1977) Volume and pressure effects on the potassium fluxes of Valonia utricularis, In: Transmembrane ionic exchange in plants (Thellier, M., Mounier, A., Demarty, M. and Dainty, J., eds.) pp. 123-137, CNRS, Paris.
2. Lelkes, P.I., Bach, D., and Miller, I.R. (1980) Interactions of auxin (IAA) with lipid membranes, In: Plant membrane transport (Spanswick,R.M., Lucas, W.J., and Dainty, J., eds.) pp. 539-540, Elsevier/North Holland, Amsterdam, New York.
3. Lelkes, P.I., Friedman, J.E. and Neeman M. (1981) French-pressed liposomes as drug carrier systems, In: Liposomes, drugs and immunocompetent cell functions. (Nicolau, C. and Paraf, A., eds.) p. 174, Academic Press, London/New York.
4. Lelkes, P.I., Naquira, D., Friedman, J.E., Rosenheck, K. and Schneider, A. (1982) Plasma membrane vesicles from bovine adrenal chromaffin cells: Characterization and fusion with chromaffin granules, In: Advances in the Biosciences, Vol. 36: Synthesis, storage and secretion of adrenal catecholamines. (Izumi F.,et al., eds.) pp. 143-150, Pergamon Press, Oxford/New York.
5. Lelkes, P.I. (1984) The use of French-pressed vesicles for efficient incorporation of bioactive macromolecules and as drug carriers in vitro and in vivo, In: Liposome technology, Vol. I, preparation of liposomes. (Gregoriadis, G.,ed.) pp. 55-65, CRC Press, Boca Raton, Fl.
6. Lelkes, P.I. (1984) Methodological aspects dealing with stability measurements of liposomes in vitro using the carboxyfluorescein - assay, In: Liposome technology, vol. III.: Targeted drug delivery and biological interaction. (Gregoriadis, G., ed.), pp. 225-246, CRC Press, Boca Raton, Fl.
7. Pollard, H.B., Ornberg, R., Levine, M., Heldman, E., Morita, K., Lelkes, P.I. and Heldman, J. (1985) Ultrastructural and biochemical aspects of biosynthesis and secretion of hormones. In: Endocrinology. (Labrie, F., Proulx, L., eds.), pp. 383-386 Excerpts Medica, Amsterdam, New York, Oxford.
8. Pollard, H.B., Ornberg, R., Levine, M., Heldman, E., Morita, K., Kelner, K., Lelkes, P.I., Brocklehurst, K., Forsberg, E., Duong, L., Levine, R. and Youdim, M. (1985) Hormone secretion by exocytosis: with emphasis on information from the chromaffin cell system. In: Vitamins and hormones, vol 42, (Aurbach,G.D. and McCormick, D.B., eds.), pp. 109-196. Academic Press, Inc., Orlando, FL.
9. Rosenheck, K. and Lelkes, P.I., eds. (1987) Stimulus-secretion coupling in chromaffin cells, 2 Vols., CRC Press, Boca Raton, FL.
10. Pollard, H.B., Burns, A.I., Stutzin, A., Rojas, E., Lelkes, P.I. and Morita, K, (1987) Cytosolic proteins as intracellular mediators of calcium action during exocytosis. In: Stimulus-secretion coupling in chromaffin cells, Vol. II, (Rosenheck, K. and Lelkes, P.I., eds.) Chap. 8, pp. 1-13 CRC Press, Inc., Boca Raton, FL
11. Lelkes, P.I. (1987) Liposome-mediated introduction of macromolecules into isolated bovine adrenal chromaffin cells, A critical evaluation of the technique and its biological implications. In: Stimulus-secretion coupling in chromaffin cells, Vol. II, (Rosenheck, K. and Lelkes, P.I., eds.) Chap.9, pp. 15-35 CRC Press, Inc., Boca Raton, FL.
12. Lazarovici, P., Primor, N., Caratsch, C.G., Munz, K., Lelkes, P.I., Loew, L.M., Shai, Y., McPhie, P., Luini, A., Contreras, M.L., Fox, J., Shih, Y.L., and Edwards, C. (1989) Action on artificial and neuronal membranes of pardaxin, a new presynaptic excitatory polypeptide neurotoxin with ionophore activity. In: Neurotoxins as tools in neurochemistry (Dolly, J.O., ed.) pp 291-240, Ellis Horwood, Chichester, England.
13. Lazarovici, P., Primor, N., Gennaro, J., Fox, J., Shai, Y., Lelkes, P.I., Caratsch, C.G., Raghunathan, G., Guy, H.R., Shih, Y.L., and Edwards, C. (1990) Origin, chemistry, and mechanisms of action of a repellent, presynaptic excitatory, ionophore polypeptide. In: Marine toxins: origin, structure, and pharmacology. (Hall, S., Stichartz, G. eds.). pp. 347-364, American Chemical Society Symposium Series, 418, Washington, D.C.
14. Lelkes, P.I. (1990) Preparation of liposomes by high pressure extrusion in the French press. In: Liposomes, a practical approach. (New, R., Mayhew, E., eds) pp. 49-52 IRL Press, Oxford, Washington, D.C.
15. Lelkes, P.I. and Pollard, H.B. (1990) Cytoplasmic determinants of exocytotic membrane fusion. In: Membrane fusion, (Editors: J. Wilschut and D. Hoekstra), pp. 511-551 Marcel Dekker, New York.\
16. Gao, H., Lelkes, P.I., Edgerton, J.R., Flemma, R.J. and Christensen, C.W. (1990) Endothelialized latissimus dorsi pouches as possible replacements for cardiac muscle. In: Cardiovascular science and technology: basic and applied, II (Norman, J., ed.) pp. 374-376 Oxymoron Press, Boston.
17. Lelkes, P.I., Samet, M.M., Gal, R., and Amrani, D. (1990) Towards endothelialization of cardiac assist devices. In: Cardiovascular science and technology: basic and applied, II (Norman, J., ed.) pp 377-379 Oxymoron Press, Boston.
18. Lelkes, P.I., and Unsworth, B.R. (1992) The role of heterotypic interactions between endothelial cells and parenchymal cells in organspecific differentiation: a possible trigger for vasculogenesis. In Angiogenesis in health and diseases (Maragoudakis, M.E., Gullino, P. and Lelkes, P.I., eds.) pp. 27-41.
19. Lelkes, P.I., Samet, M.M., Christensen, C.W. and Amrani, D.L. (1992) Factitious angiogenesis: endothelialization of artificial cardiovascular prostheses. In: Angiogenesis in health and diseases (Maragoudakis, M.E., Gullino, P. and Lelkes, P.I., eds.), pp. 339-351.
20. Maragoudakis, M.E., Gullino, P. and Lelkes, P.I., eds. (1992) Angiogenesis in health and diseases, pp. 1-402, Plenum Press, New York and London.
21. Maragoudakis, M.E., Gullino, P. and Lelkes, P.I. eds. (1994) Angiogenesis: Molecular Biology, Clinical Aspects, pp.1-372, Plenum Press, New York and London..
22. Papadimitriou, E., Unsworth, B.R., Maragoudakis, M.E. and Lelkes, P.I. (1994) Quantitative analysis of extracellular matrix formation in vivo and in vitro. In: Angiogenesis: Molecular Biology, Clinical Aspects (Maragoudakis, M.E., Gullino, P., and P.I. Lelkes eds.), Plenum Press, New York and London, pp. 291-306.
23. Lelkes, P.I., Manolopoulos, V.G., Chick, D. and Unsworth, B.R. (1994) Endothelial cell heterogeneity and organ-specificity. In: Angiogenesis: Molecular Biology, Clinical Aspects (Maragoudakis, M.E., Gullino, P., and Lelkes, P.I., eds.), Plenum Press, New York and London, pp. 15-28.
24. Lelkes, P.I., Chick, D.M., Samet, M.M., Nikolaychik, V., Thomas, G.A., Hammond, R.L., Isoda, S. and Stephenson, L.W. (1994) Factitious Angiogenesis: Not so factitious anymore? The role of angiogenic processes in the endothelialization of artificial cardiovascular prostheses. In: Angiogenesis: Molecular Biology, Clinical Aspects (Maragoudakis, M.E., Gullino, P., and Lelkes, P.I., eds.), Plenum Press, New York and London, pp.321-331.
25. Shilderman-Bloch, E., Abu-Raya,S., Rasouly, D., Furman, O., Trumbovler, V., Shavit, D., Lelkes, P.I., Shohami, E., Gutman, Y., and Lazarovici, P. (1996) The role calcium, protein kinase C, pertussis toxin substrates and eicosanoids on pardaxin induced dopamine release from PC12 pheochromocytoma cells. In: Biochemical Aspects of Marine Pharmacology (Lazarovici, P., Spira, M.E.,and Zlotkin, E., eds.), Alaken, Inc., Fort Collins, CO, pp.158-186.
26. Lelkes, P.I., Manolopoulos, V., Silverman, M., Zhang, S., Karmiol, S., and Unsworth, B.R. On the possible role of endothelial cell heterogeneity in angiogenesis (1996) In: Molecular, Cellular, and Clinical Aspects of Angiogenesis.(M.E. Maragoudakis, ed.) Plenum Press, New York and London, pp 1-19.
27. Lelkes, P.I., Nikolaychik, V.V., Samet. M.M., Wankowski, D.M., and Chekanov, V. (1996) Factitious angiogenesis III: How to successfully endothelialize artificial cardiovascular bioprostheses by employing natural angiogenic mechanisms. In: Molecular, Cellular, and Clinical Aspects of Angiogenesis.(M.E. Maragoudakis, ed.) Plenum Press, New York and London, pp 229-240.
28. Nikolaychik, V.V., Silverman, M.D., Samet, M.M., Wankowski, D.M. and Lelkes, P.I. (1997) Durability of endothelial cell monolayers inside a beating cardiac prosthesis, Artificial Heart VI, (Akutsu, H., ed.) Springer Verlag, pp. 498-502.
29. Nikolaychik, V.V., Chekanov, V.S., Silverman, M.D., Samet, M.M., Schmidt, D.H., and Lelkes, P.I. (1997) Successful dynamic cardiomyoplasty with pharmaceutical support, Artificial Heart VI (Akutsu, H., ed.), Springer Verlag,, pp 130-134.
30. Thomas, G. A., Lelkes, P.I., Chick, D.M., Hammond, R.L., Lu, H., Nakajima, H., Isoda, S., Nakajima, H.O., and Stephenson, L.W. (1997) Skeletal muscle ventricles: In search of thromboresistant linings. In: Cardiac Bioassist (Carpentier, A., Chachques, J.C., and Grandjean, P.A., eds.), Futura Press, New York, Futura Publishing Co, Inc. Armonk, NY, pp. 575 - 587.
31. Unsworth, B.R., and Lelkes, P.I. (1998) Unsworth BR, Lelkes PI: The use of rotating wall bioreactors for the assembly of differentiated tissue-like organoids. In: Advances in Tissue Engineering, pp. 113-132, IBC Press, Southborough, MA. Lelkes, P.I., Hahn, K.A., Karmiol, S., and Schmidt, D.H. (1998) Hypoxia/reoxygenation enhances tube formation of cultured human microvascular endothelial cells: role of reactive oxygen species. In: Angiogenesis.(M.E. Maragoudakis, ed.) Plenum Press, New York and London,
32. Samet, M.M., Nikolaychik, V.N., and Lelkes, P.I. (1999): Surface precoating in the 1990's: the fine tuning of endothelial cell transplantation. In: Tissue Engineering of Prosthetic Vascular Grafts (P.P. Zilla and H.P. Greisler, eds.),pp 79-90. R.G. Landes, Austin TX.
33. Lelkes, P.I. (1999) Regulation of endothelial cells by mechanical forces. Harwood Academic Press, London, U.K.,
34. Samet, M.M. and Lelkes , P.I. (1999) The hemodynamic environment of endothelium in vivo and its simulation in vitro In: Regulation of endothelial cells by mechanical forces (P.I. Lelkes, ed.), pp. 1-32, Harwood Academic Press, London, U.K.
35. Lelkes, P.I. (1999) Differential regulation of endothelial cell surface molecules by diverse hemodynamic forces. In: Regulation of endothelial cells by mechanical forces (P.I. Lelkes, ed.), pp. 221- 248, Harwood Academic Press, London, U.K.
36. Lelkes, P.I., and Waters, C.R. (2000) Reactive Oxygen Species and Angiogenesis. In: Angiogenesis in Health and Disease. (G.M. Rubanyi, ed.) pp199-214, Marcel Dekker Inc. New York, Basel.
37. Unsworth, B.R., and Lelkes, P.I. (2000) Growing tissues in microgravity. In: Principles of Tissue Engineering, 2nd Edition, (R. Lanza, R. Langer, J. Vacanti, eds), pp. 157-164, Academic Press, San Diego, CA, USA.
38. Lelkes, P.I. and Unsworth, B.R. (2002) Neuroendocrine Tissue Engineering in RWV Bioreactors. In: Methods in Tissue Engineering, (A. Atala, ed.), pp 371- 382, Academic Press, San Diego, CA, USA.
39. Wei, Y., Lelkes, P.I., MacDiarmid, A.G., Guterman, E., Cheng, S., Palouian, K., and Bidez, P. (2004) "Electroactive Polymers and Nanostructured Materials for Neural Tissue Engineering" in "Contemporary Topics in Advanced Polymer Science and Technology" (Qi-Feng Zhou and Stephen Z.D, Cheng, eds.) pp. 430-436, Peking University Press, Beijing, China, ISBN 7-301-07141-148.
40. Guo, Y., Wei, Y., Lelkes, P.I., Ko, F.K., Zhou, Y., and Levon, K, (2004) "Synthesis and characterization of thiolated aniline oligomers for potential bioconjugation use", Polymeric Materials: Science and Engineering Vol. 91, pp. 585-586, 2004. CODEN: PMSEDG ISSN:0743-0515. AN 2004:670315
41. Lelkes, P.I., Unsworth, B.R., Saporta, S. Cameron D.F. and Gallo, G. (2005) Culture of 3-D Neuronal and Neurendocrine Tissue Constructs. In: Culture of Cells for Tissue Engineering: Edited by G. Vunjak Novakovic & R.I. Freshney, chapter 14, pp. 373-413. J. Wiley, Indianapolis, IN, USA
42. Lazarovici, P., Li, M., Perets, A., Mondrinos, M.J., Lecht. S., ,Koharski C.D, , Bidez, P.R. III , Finck., CM., and Lelkes, P.I. (2006) Intelligent Biomatrices and Engineered Tissue Constructs: in vitro Models for Drug Discovery and Toxicity Testing. In: Drug Testing In Vitro: Breakthroughs and Trends in Cell Culture Technology (U. Marx, and V. Sanding, eds.). pp 1- 57, J. Wiley Indianapolis, USA.
43. Lecht, S. , Puxeddu, I., Levi-Schaffer, F., Reich, R., Davidson, B., Schaefer, E., Marcinkiewicz, C., Lelkes, P.I., and Lazarovici, P., (2008) Nerve growth factor - a neurotrophin with angiogenic activity in: ‘Angiogenesis-Basic Science and Clinical Applications’ (M. E. Maragoudakis and E. Papadimitriou, eds.), chapter 6, pp. 99-113. Research Signpost Publishers, Kerala India
44. Lelkes, P.I., Li, M., Perets, A., Lin, L., Han, J., and Woerdeman, D.L. (2009) Electrospinning of natural proteins for tissue engineering scaffolding in: Handbook of Natural-based Polymers for Biomedical Applications Rui L.Reis editor), Woodhead Publishing Ltd, in press
45. Finck, C.M., Roszell, B, and Lelkes, P.I. (2009) 3-D in vitro models in vitro for Lung Tissue Engineering. in: Cell-Based Therapies Lung Diseases. Dame Julia Polak, ed. Wiley, in press


More than 400 published abstracts of presentations at local, national, and international conferences
Education:
Ph.D. (Dr. rer nat), RWTH Aachen, Germany, 1977
M.Sc. (Dipl. Phys.), RWTH Aachen, Germany, 1974
Active Research Projects:
Tissue Engineering and Regenerative Medicine:

Soft Tissues: Lung, Heart, Spinal Cord Injury, Vascular Grafts,

Musculoskeletal Tissues: Smart Scaffolds for Bone Regeneration, Bioactive Surgical Tools
Publications:
see biosketch
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