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BIOMED Faculty Details: Margaret A. Wheatley, Ph.D.
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Margaret A. Wheatley, Ph.D.   [Details
John M. Reid Professor, School of Biomedical Engineering, Science & Health Systems
Other, Other
Office: LeBow 48-A  Email:
Phone: 215.895.2232   Fax: 215.895.5837
Laboratory Web Page: Click Here to Visit Laboratory Web Page
Research Keywords:
Ultrasound contrast agent development (tumor targeting and triggered drug delivery), controlled release technology (bioactive compounds), microencapsulated allografts (ex vivo gene therapy) for spinal cord repair.
B.A. Chemistry, Oxford University, 1971
M.A. Biochemistry, Oxford University, 1974
Ph.D. Chemical Engineering, University of Toronto, 1982
R. Basude and M.A. Wheatley, Generation of Ultras-harmonics in surfactant-based Ultrasound Contrast Agents- Use and advantages, Ultrasonics accepted September 2001

P. Narayan, M.Wheatley and B. Farouk, “A numerical study of the generation and propagation of thermoacoustic Waves in water”, JASA, submitted August 1999

M. Wheatley, “Composition of contrast microbubbles: Basic chemistry of encapsulated and surfactant coated bubbles” In Ultrasound Contrast Agents: Basic Principles and Clinical Practice, Second Edition, edited by B. Goldberg, J. Raichlen and F. Forsberg , Martin Dunitz, London, 2001

P. Narayan, D. Marchant and M. A. Wheatley, “Optimization of spray drying by factorial design as a technique to produce hollow microspheres for ultrasound imaging”, J. Biomed. Mat. Sci. 56 333-341 2001

Chris A.Tobias, Nikhil O. Dhoot, Margaret A. Wheatley, Alan Tessler, Marion Murray, and Itzhak Fischer, Grafting of encapsulated BDNF-producing fibroblasts into the injured spinal cord without immune suppression in adult rat J. Neurotrauma , 18(3), 287-301 (2001)

R. Basude, J. Duckworth and M.A. Wheatley, “Influence of environmental conditions on a surfactant-stabilized contrast agent:ST68”, Ultrasound in Med. and Biol 26(4) 621-628 (2000)

P. Narayan and M. A. Wheatley, Preparation and Characterization of Hollow Microcapsules for use as Ultrasound Contrast Agents. Polymer Eng. and Sci.. 39 (11):2242-2255 (1999)

W. Shi, F. Forsberg, A. Hall, R. Chiao, J-B Liu, S. Miller, K. Thomenius, M. Wheatley and B. Goldberg, “Subharmonic Imaging with Microbubble Contrast Agents: Initial Results, Ultrasonic Imaging 21:79-94 (1999)

F. Forsberg, R. Basude, J. B. Liu, J. Alessandro, W. T. Shi, N. M. Rawool, B. B. Goldberg, M. Wheatley: “Effect of Filling Gasses on the Backscatter from Contrast Bubbles: Theory and in vivo measurements” Ultrasound in Biol. and Med. 25(8):1203-1211 1999

M.A. Wheatley, D. El-Sherif, R. Basude, R. Shimp amd P. Narayan, “Ultrasound-Triggered Drug Delivery with Contrast Imaging: Effect of Microencapsulation Method” In. Biomedical Materials-Drug delivery, Implants and Tissue Engineering, ed. Thomas Neenen, M. Marcalongo and R. Vlentini, MRS Symp. Proc. 550:113-117 (1999)

M.A. Wheatley and P. Narayan, “Diagnostic Use of Microcapsules”, in Encyclopedia of Controlled Drug Delivery. E. Mathiowitz Ed. CRC Press Baton Rouge, FL. 1999, pp313-340

M. A. Wheatley, J. Alessandro, F. Forsberg, B. B. Goldberg and W. Wang: “Development of a new Surfactant-based Ultrasound Agent” Proc. of AAMI 97, AAMI, Arlington, VA, pp. 58, (1997).

M. Wheatley, F. Forsberg, N. M. Rawool, W. T. Shi, J. Alessandro and B. B. Goldberg: “Harmonic and Conventional US Imaging with SF6 Filled Microbubbles” Radiology, 205(P):417, (1997).

W. T. Shi, F. Forsberg, M. Gupta, J. Alessandro, M. A. Wheatley, and B. B. Goldberg: “Subharmonic Response of a New US Contrast Agent” Radiology, 205(P):353, (1997).

F. Forsberg, Y. Wu, I.R.S. Makin, W. Wang and M. A. Wheatley, “Quantitative acoustic characterization of a new surfactant based ultrasound contrast agent”. Ultrasound in Med. and Biol. 23 (8):1201-1208, (1997)

M. Gupta, W. T. Shi, J. Alessandro, F. Forsberg, Y. Wu, R. Bandue and M. A. Wheatley: Harmonic Properties of a New Surfactant Based Ultrasound Contrast Agent. Ultrasonic Imaging, 19(1):81, (1997).

F. Forsberg, J.B. Lui, D.A. Merton, W. Wang, M.A. Wheatley and B.B. Goldberg: Air-filled versus Perfluorocarbon-filled microbubbles for US contrast. Radiology, 201(P):153, (1996)

M. A. Wheatley, I. Makin, F. Forsberg, Y. Wu and W. Wang, "Development and Characterization of a New Diagnostic Contrast Agent" Medical Physics 23, (6), pp. 1061 (1996).

Wenhua Wang, Chris Moser and Margaret A. Wheatley, "Langmuir Trough Study of Surfactant Mixtures used in the production of a New Ultrasound Contrast Agent Consisting of Stabilized Microbubbles" J. Phys. Chem. 100(32)13815-13821, (1996)

F. Forsberg, N. M. Rawool, D. A. Merton, J. B. Liu, W. Wang, P.Kankate, J. Alessandro, B.B. Goldberg and M.A. Wheatley: Comparison of Air and Perfluorocarbon Filled Microbubbles for
Ultrasound Contrast Studies. Proc. IEEE Ultrason. Symp., M. Levy, S. C. Schneider & B. R. McAvoy (eds.), IEEE, New York, 2, pp. 1337 - 1340, (1996).

Margaret A. Wheatley, Linda Schadler and Banu Onaral “The GOES Project: A successful Outreach Program that Introduces Girls to Engineering” Proc. of Women in Engineering Conference, ‘Capitalizing on Todays Challenges’, Denver Co. June 1-4 pp 233-238 (1996)

Raj Mutharasan, Wayne Magee, Margaret Wheatley and Young Lee, "Thematic Introduction to Engineering Biotechnology: Gateway Experiences" Proc. Ann. Conf. ASEE. Anaheim, California, June 25-28 1995

M.A. Wheatley and S. Singhal, "Structural Studies on Stabilized Microbubbles: Development of a Novel Contrast Agent for Diagnostic Ultrasound" Journal of Reactive Polymers 25:157-166 (1995)

F. Forsberg, Y. Q. Wu., I. R. S. Makin, J. Srinivasan, W. Wang and M.A. Wheatley: In vitro and in vivo characterization of a new surfactant stabilized ultrasound contrast media. Proc. IEEE Ultrason. Symp., M. Levy, S. C. Schneider & B. R. McAvoy (eds.), IEEE, New York, 2: 1129 -1132, (1995)

T. Feeser and M.A. Wheatley ""Microencapsulated Liposomes: Lipid Stability and Influence of Entrapped Species " Proceed. Intern. Symp. Contol. Rel. of Bioact. Mater. 21 (1994)

M.A. Wheatley, D. Alford and C-Y S. Hsiao, "pH-Dependent pore formation in liposomes: An approach to triggered Release" Proceed. Intern. Symp. Contol. Rel. of Biocat. Mater. 21 (1994)

V.L. Newhouse and M.A. Wheatley edit. Special issue IEEE transactions on Ultrasonics, Ferroelectronics and Frequency Control 41(1):67-160 (1994)

S. Singhal, C.C. Moser and M.A. Wheatley, "Surfactant-stabilized Microbubbles as Ultrasound Contrast Agents: Stability Study of Span 60 and Tween 80 mixtures Using a Langmuir Trough" Langmuir. 9:2426-2429, (1993)

Teresa Feeser and M.A. Wheatley, "Pulsatile Drug Release From Polymeric Microcapsules" Proc. 20th Symp. on Controlled Release of Bioactive Materials, Washington, D.C. 20 Ed. T. J. Roseman , N.A. Peppas and H.L. Gabelnick, pp32-33 (1993).

M.A. Wheatley, Peng Shen, Shruti Singhal and Beth Schrope, "Biomedical Aspects of Ultrasound Contrast using Polymeric Microspheres" Polymeric: Materials Science and Engineering 66:93-94, (1992)

Beth Schrope, Peng Shen and Margaret A. Wheatley "Polymeric Systems for Diagnostic Ultrasound Contrast Agents" pp 371-384 in Cosmetic and Pharmaceutical Applications of Polymers, C.G. Gebelein Ed. Plenum Publishing Corp., New York. (1991)

M.A. Wheatley and R. Langer, "Coated Alginate Microspheres: Factors Influencing the Controlled Delivery of Macromolecules. J. Appl. Poly. Sci. 43:2123-2135, (1991)

P. Shen, Schrope B and M.A. Wheatley. "Polymer coated Microbubbles: A Novel Contrast Agent for Diagnostic Ultrasound" Polymer Preprints, 31(1):228, (1990)

M.A. Wheatley, Schrope B., and Shen P. "Contrast Agents for Diagnostic Ultrasound: Develop-ment and Evaluation of Polymer Coated Microbubbles" Biomaterials, 11(9):713-717, (1990).

M.A. Wheatley, Schrope B., and Shen P. "Polymeric Systems for Diagnostic Ultrasound" Polymeric: Materials Science and Engineering 63:144-7 (1990).

P.G. Kibat, Y. Igari, M.A. Wheatley, H.N. Eisen and R. Langer, "Enzymatically Activated Microencapsulated Liposomes can Provide Pulsatile Drug Release" FASEB 4, 2533-2539 (1990)

P. Shen, B. Schrope and M.A. Wheatley, "Polymer-Coated Microbubbles: A Novel Contrast Agent for Diagnostic Ultrasound" Polymer Preprints 31(1):228, (1990).

C.M. Lancaster and M.A. Wheatley, "Drug Delivery to the Colon: Polymer susceptibility to Degradation by Colon Contents." Polymer Preprints 30 (1):480, (1989).

M. A. Wheatley, J. Dent, E. B. Wheeldon and P. Smith. "Nasal Drug Delivery: An In Vitro Characterization of Transepithelial Electrical Properties and Fluxes in the Presence or Absence of Enhancers." J. Contr. Rel., 8:167-177, (1988).

M. A. Wheatley, J. Dent, P. Smith and E. Wheeldon. "Use of Ussing Chamber for Investigation of Drug Delivery Across Viable Nasal Tissue Membranes." Proc. Intern. Symp. Control. Rel. Bioact. Mater., 14. Ed. P.I. Lee and B. A. Leonhardt. Contro. Rel. Soc. Inc., pp. 25, (1987).

M. A. Wheatley, and R. Langer. "Particles as Drug Delivery Systems." Particulate Science and Technology, 5(1):54-63, (1987).

M. A. Wheatley, H. Eisen & R. Langer. "Alginate/Poly-L-Lysine Microcapsules as a Vehicle for Controlled Release of Macromolecules." Proc. 12th Int. Symp. on Control. Rel. of Bioactive Mat. Ed. N. A. Peppas and R. J. Haluska. Contr. Rel. Soc. Inc., pp. 245, (1985).

M. A. Wheatley and R. Langer. "Polymeric Microspheres for Controlled Drug Delivery." In Microspheres and Drug Therapy, Pharmaceutical, Immunological and Medical Aspects. Ed. S.S. Davis, et. al. Elsevier Science Publishers, pp. 341, (1984).

F. V. Lamberti, R. A. Evangelista, M. A. Wheatley, J. Blysnuik & M. V. Sefton. "Micro-encapsulation of Mammalian Cells in Polyacrylate." J. Appl. Biochem. Biotechnol.., 10:101-104 (1984).

F F. V. Lamberti, R. A. Evangelista, M.A. Wheatley, J. Blysnuik, and M. V. Sefton. "The Use of Polyacrylates in the Microencapsulation of Viable Tissue Cells." In Polymers and Biomaterials. Ed. S. W. Shaleby, et. al. p39-50, (1984).

F.F. V. Lamberti, M. A. Wheatley, R. A. Evangelista, and M. V. Sefton. "The Use of Poly-acrylates in the Microencapsulation of Viable Tissue Cells." Polym. Prepr., 24(1):75-76, (1983)
M. A. Wheatley and C. R. Phillips."Enzymatic Properties of Immobilized Alcaligenes faecalis Cells with Cell-associated b-glucosidase Activity."Biotechnol. Bioengr. XXVI:583-589, (1984)

M. A. Wheatley & C. R. Phillips. "Temperature Effects During Polymerization of Polyacrylamide Gels Used for Bacterial Cell Immobilization," Biotechnol. Bioengr. XXV:623-626, (1983).

M. A. Wheatley and C. R. Phillips. "The Influence of Internal and External Diffusion Limitations on the Observed Kinetics of Immobilized Whole Bacterial Cells with Cell-associated b-glucosidase Activity." Biotechn. Ltrs.., 5(2):79-84, (1983).

M. A. Wheatley and C. R. Phillips. "Immobilization of Whole Bacterial Cells to Aid in the Saccharification of Cellulosic Carbohydrate Substrates." Advances in Biotechnology, II, 47-54. Eds. M. Moo-Young and C. W. Robinson, Pergamon Press, (1981).

C. R. Phillips, D. Granatstein and M. A. Wheatley. "The Potential of Biomass to Substitute for Petroleum in Canada." ACS Symposium Series, 90. Chemistry for Energy, 133-164, (1979).

M. A. Wheatley and M. Moo-Young. "Degradation of Polysaccharides by Endo and Exo Enzymes. Dextran-Dextranase Model Systems." Biotechnol. Bioengr. XIX:219, (1976).

P. J. Robinson, M. A. Wheatley, J-C. Janson, P. Dunnill and M. D. Lilly. "Pilot Scale Affinity Chromatography: Purification of ß-Galactosidase." Biotechnol. Bioengr.., XVI:1103-112, (1974)
"Extracorporeal Reactors Containing Immobilized Species" Bernstein, Wheatley and Langer. U.S. Patent #4,863,611 September 5, 1989.

"System for Delayed and Pulsed Release of Biologically Active Substances." Wheatley, Langer, and Eisen. U.S Patent #4,900,556 February 13, 1990.

"Systems and Apparatus for Delayed and Pulsed Release of Biologically Active Substances." Wheatley, Langer, and Eisen. U.S. Patent #4,921,757 May 1, 1990.

"System for Controlled Release of Biologically Active Compounds." Wheatley, Langer, and Eisen. U.S. Patent #4,933,185 June 12, 1990.

"Surfactant-Stabilized Microbubbles Mixtures, Process for Preparation and Methods of Using same" Wheatley, Shen, Goldberg and Singhal. U.S. Patent #5,352,436 October 4, 1994.

"Gas-filled Polymeric Microcapsules for Ultrasound Imaging" Cohen, Andrianov, Wheatley, Allcock and Langer. U.S. Patent #5,487,390 January 30, 1996.

"Polymeric Microcapsules Containing Agents for Imaging" Cohen, Andrianov, Wheatley, Allcock and Langer. U.S. Patent #5,562,099 October 8, 1996.

“Hollow Polymer Microcapsules and Method of Producing Same” Wheatley and Narayan. U.S. Patent #5,955,143 September 21, 1999.

“Surface-stabilized Microbubbles for Use in Ultrasound Contrast and Drug Delivery" Basude and Wheatley. Drexel provisional application 0007 June 1999.

“Method of Enhancing Doppler Perfusion and Imaging Techniques via Ultraharmonics” Basude and Wheatley. Drexel provisional application 0008 June 1999.

"Nanofiber Mat with Capability to Deliver Bioactive Compounds" Wheatley, Ko, El-Sherif, Dhoot, Kanakasaba, Benjelloun and Han. Drexel provisional application.

"Hollow Polymeric Micro and Nanospheres for Diagnostic Imaging and Drug Delivery" El-Sherif and Wheatley. Drexel provisional 0054 March 30, 2001.
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