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Kenneth A. Barbee, Ph.D.
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Associate Professor, Associate Director for Research, School of Biomedical Engineering, Science & Health Systems
Office: Bossone 7-703 Email: barbee@drexel.edu
Phone: 215.895.1335 Fax: 215.895.4983
Personal Web Page: Click Here to Visit Personal Web Page
Laboratory Web Page: Click Here to Visit Laboratory Web Page
Research Keywords:
Cellular biomechanics of neural and vascular injury, mechanotransduction in the cardiovascular system, mechanical control of growth and development for wound healing and tissue engineering.
Education:
Ph.D., Bioengineering, University of Pennsylvania, 1991
M.S., Bioengineering, University of Pennsylvania, 1988
B.S., Engineering Science and Mechanics, University of Tennessee, 1986
Publications:
DiMilla PA, K Barbee, and DA Lauffenburger. "A Mathematical Model for the Effects of Adhesion and Mechanics on Cell Locomotion.? Biophys. J. 60:15-37 (1991).
Barbee KA, PF Davies, and R Lal. ?Shear Stress-induced Reorganization of the Surface Topography of Living Endothelial Cells Imaged by Atomic Force Microscopy.? Circ. Res. 74:163-171 (1994).
Barbee KA, EJ Macarak, and LE Thibault. ?Strain Measurements In Cultured Vascular Smooth Muscle Cells Subjected to Mechanical Deformation.? Ann. Biomed. Eng. 22:14-22 (1994).
Davies PF and KA Barbee. ?Endothelial Cell Surface Imaging: Insights Into Hemodynamic Force Transmission And Transduction.? News In Physiol. Sci. 9:153-157 (1994).
Barbee KA, T Mundel, R Lal, and PF Davies. ?Sub-Cellular Distribution of Shear Stress at the Surface of Flow-Aligned and Nonaligned Endothelial Monolayers.? Am. J. Physiol. 268: H1765-H1772 (1995).
Davies PF, KA Barbee, R Lal, A Robotewskyj, and ML Griem. ?Hemodynamics and Atherogenesis: Endothelial Surface Dynamics in Flow Signal Transduction.? Ann. NY Acad. Sci. 748:86-103 (1995).
Davies PF, T Mundel, and KA Barbee. ?A Mechanism for Heterogeneous Endothelial Responses to Flow In Vivo and In Vitro.? J. Biomech. 28(12): 1553-1560 (1995).
Barbee KA, JA Morrow, and SC Meredith. ?Deconvolution of Gel Filtration Chromatographs of Human Plasma Lipoproteins.? Anal. Biochem. 231: 301-308 (1995).
Barbee KA. ?Changes in Surface Topography in Endothelial Monolayers with Time at Confluence: Influence on Subcellular Shear Stress Distribution Due to Flow.? Biochem. Cell Biol. 73: 501-505 (1995).
Davies, PF, KA Barbee, MV Volin, A Robotewskyj, J Chen, L Joseph, ML Griem, MN Wernick, E Jacobs, DC Polacek, N DePaola, and AI Barakat. ?Spatial Relationships in Early Signaling Events of Flow-mediated Endothelial Mechanotransduction.? t. Ann. Rev. Physiol. 59: 527-49 (1997).
Barbee, KA, J Yazdi, B Abai, S Croul, R Fijan, and LE Thibault ?An In Vivo Model for the Acute Response of Neural Tissue to Traumatic Loading.?, International Research Council on the Biokinetics of Impact pp. 95-105 (1999).
Blackman, BR, KA Barbee, and LE Thibault. ?In Vitro Cell Shearing Device to Investigate the Dynamic Response of Cells in a Controlled Hydrodynamic Environment.? Ann. Biomed. Engin. 28: 263-272 (2000).
Blackman, BR, LE Thibault, and KA Barbee. ?Selective Modulation of Endothelial Cell [Ca2+]i Response to Flow by the Onset Rate of Shear Stress.? . J. Biomech. Engin. 122(3): 274-282 (2000).
Blackman, BR, TN Tulenko, and KA Barbee. ?Cholesterol Enrichment Suppresses Endothelial Cell Intracellular Calcium Mobilization in Response to Mechanical Stimulation.? Arterioscler. Thromb. Vasc. Biol. (Submitted, 2001).
Barbee, KA, AB Bhavnani, and EJ Macarak. ?An In Vitro Model of Vascular Smooth Muscle Injury During Angioplasty.? J. Appl. Physiol. (Submitted, 2001)
Barbee, KA ?The Role of Spatial Gradients of Shear Stress on the Endothelial Response to Flow in Atherogenesis.? Invited Review in Special Issue of Ann. Biomed. Engin. on ?Biomechanical Approaches to Atherosclerosis? Ed. Morton Friedman (to appear 2001).
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