Seminar - The Role of the Experimental Animal Model in Orthopaedic Research
Date: October 28, 2011
Time: 4:00 PM
Location: Papadakis Integrated Sciences Building, Room: Auditorium
Speaker(s):
Thomas P. Schaer, VMD
Department of Clinical Studies New Bolton Center
University of Pennsylvania School of Veterinary Medicine
Details:
Scientific discoveries for improvement of human health must be translated into practical applications. Such discoveries typically begin at "the bench" with basic research, then progress to the clinical level. In particular, the field of musculoskeletal research (orthopaedics) can look back on a long and productive history of cross-fertilization between veterinary and human surgeons resulting in the development of innovative therapies for their patients. Pre-clinical studies using animal models continue to play a very important role in the evaluation of efficacy and safety of new medical devices before their use in human clinical studies. This seminar provides practical insight into the design, execution and analytical methodologies of pre-clinical large animal studies. In addition the increasing complexity of regulatory scrutiny at the preclinical level is being discussed.
WATCH WEBCAST
Biosketch:
Dr. Thomas Schaer is the Director of the Comparative Orthopaedic Research Laboratory in the Department of Clinical Studies at the University of Pennsylvania School of Veterinary Medicine. Dr. Schaer trained in both human and veterinary medicine, and completed an internship, residency and lecturership in large animal/equine surgery. He is a member of the UPENN ULAR Veterinary Care Advisory Board as well as the UPENN IACUC, and is very involved in animal welfare and regulatory issues at the University level. His primary interests are in clinical orthopaedic trauma, joints, spine, and CMF with a particular interest in the application of novel materials for functional restoration of the musculoskeletal system. In 2005 he started to develop a training program to provide an incubator environment across traditional academic boundaries for undergraduate and graduate education in orthopedic translational and regulatory R&D. He has developed an expertise in large animal surgical models for device development and evaluation, musculoskeletal tissue replacement and repair. These animal models have been developed through numerous funding sources, including both private industry and federal funding agencies. He has a significant amount of experience with developing animal models through discussions with cross-functional groups in the orthopedic biotech arena. Dr. Schaer continues to develop and refine large animal models to improve the predictability of clinical outcome in orthopedic large animal models as novel therapies are being translated from bench-to-bedside. He has worked as a study director/project manager for over six years, designing and writing preclinical protocols to match the requirements of multidisciplinary core teams. He has interfaced with regulatory colleagues in the submission of GLP (58CFR21 & 11CFR21)/Pivotal studies to the FDA and coordinated the preclinical requirements of these submissions in GLP/Pivotal studies. Since the inception and implementation of his research program in 2005, Dr. Schaer has trained numerous fellows, residents, veterinary students and pre-vet students in translational orthopaedic research. He is a consulting surgeon with various industry-led ventures in orthopaedic trauma, spine and sports medicine.
Directions:
The Papadakis Integrated Sciences Building is located on the northeast corner of 33rd and Chestnut Streets.
|
