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Ph.D. Thesis Defense - Development and Characterization of a Novel Metal Ion Binding-Mediated Drug Delivery Mechanism for Biomedical Applications

Master's Thesis Defense - Micro-grooved Surface Topography Does Not Influence Fretting Corrosion of Tapers in THA: Classification and Retrieval Analysis

Master's Thesis Defense - Conversion of Murine Embryonic Stem Cells to Neural Precursor Cells, Astrocytes and Neurons by Differentiation and Corticogenesis and Its Characterization

Master's Thesis Defense - Development of Ultrasound-Triggered Antibiotic Release Clip to Prevent Spinal Fusion Infection

Seminar - Nanomechanics of Murine Synovial Joint Tissues: A Novel Interdisciplinary Approach to Uncover the Pathogenesis of Osteoarthritis

Ph.D. Thesis Defense - Interaction of Non-Thermal, Non-Cavitational 20-100 KHz Ultrasound and Biological Tissue: Modeling, Experimental Validation, and Clinical Implications

EVENTS Archive
Special Seminar - Biomaterials and Tissue Engineering Strategies for Engineering Neural Interfaces and Neural Repair
Date: March 17, 2010
Time: 12:30 PM
Location: Bossone Research Enterprise Center, Room: 709

Yinghui Zhong, PhD
Postdoctoral Fellow
Cleveland Clinic
Cleveland, OH

Implantable neural prostheses can have significant implications for the treatment of a wide variety of sensory and movement disorders. However, the long-term performance of the implanted neural prostheses is compromised by the formation of glial scar around these devices, which is a typical consequence of the inflammatory tissue reaction to implantation-induced injury in the CNS. The glial scar is inhibitory to neurons and forms a barrier between the electrodes and neurons. We developed a novel biomaterial-based drug delivery system for neural prostheses to reduce the inflammatory tissue response and improve long-term functional recording. This system enabled sustained release of bioactive agents including proteins, neuropeptide, and small molecule drugs from micron-scale neural prostheses. In vivo study demonstrated that local release of anti-inflammatory agent from implanted neural probes effectively attenuated the cellular and molecular inflammatory response, and reduced neuronal loss in the vicinity of the neural probes. This work represents a promising approach to attenuate astroglial scar around the implanted neural prostheses, and improve the long-term recording stability. Further, I will present my research on using neural stem cells for spinal cord repair. I studied the therapeutic potential of a population of neural stem cells discovered in our laboratory in a spinal cord demyelination model. My study demonstrated that these neural stem cells were capable of differentiating into myelin-forming oligodendrocytes in a demyelinated environment without external manipulation, indicating that they have great potential to be used for spinal cord remyelination and functional repair. In concluding this presentation, I will discuss the challenges for engineering neural interfaces and neural repair, and how biomaterials and tissue engineering strategies can help achieve these goals.


The Bossone Research Enterprise Center is located at the corner of 32nd and Market Streets.

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