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Speaker(s):
Blaine Christiansen, Ph.D.
Center for Advanced Orthopedic Studies
Harvard Medical School
Beth Israel Deaconess Medical Center

Details:
Systemic bone loss occurs throughout adulthood, and is accelerated by menopause or conditions of reduced mechanical loading. Currently, 55% of people over 50 years of age have low bone mass, which can lead to bone fragility and an increased risk of fracture. It is therefore critical to understand important factors affecting bone fragility, including mechanisms of osteoporotic fractures and the response of bone to altered mechanical loading environments. This presentation will first discuss the response of the mouse skeleton to increased mechanical loading environments due whole-body vibration, as well as the development and validation of a novel method for vibrational loading of mice. Next, preliminary studies investigating the response of mice to reduced mechanical loading environments will be presented. Finally, studies investigating biomechanical mechanisms of vertebral fracture in humans using a computational model will be described.

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The Bossone Research Enterprise Center is located at the corner of 32nd and Market Streets.