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Seminar - Molecular and Vascular Medicine
Date: May 13, 2005
Time: 4:00 PM
Location: Bossone Research Center, Room: 1st Flr. Auditorium

Speaker(s):
Dr. William Aird
Associate Professor of Medicine
Harvard Medical School
Deputy Director of the Vascular Biology Center and Chief
Division of Molecular and Vascular Medicine at Beth Israel Deaconess Hospital

Details:
The endothelium is a highly metabolically active organ that is involved in a many physiological processes, including the control of vasomotor tone, barrier function, leukocyte adhesion and trafficking, inflammation, and hemostasis. Endothelial cell phenotypes are differentially regulated in space and time. Endothelial cell heterogeneity has important implications for developing strategies in basic research, diagnostics and therapeutics.

The goals of this talk are to:
- Consider mechanisms of endothelial cell heterogeneity.
- Discuss the bench-to-bedside gap in endothelial biomedicine.
- Revisit definitions for endothelial cell activation and dysfunction.
- Propose new goals in diagnosis and therapy.

Biosketch:
Dr. William Aird, Deputy Director of the Vascular Biology Center is currently Associate Professor of Medicine at Harvard Medical School and Chief, Division of Molecular and Vascular Medicine. Dr. Aird is a clinician scientist who runs a large NIH funded research lab, and who attends on both Hematology and Medicine services. His major research contributions include the molecular characterization of endothelial cell heterogeneity, the elucidation of the regulatory mechanisms underlying vascular bed-specific gene expression, and the dissection of site-specific signaling pathways in the intact endothelium. Dr. Aird is founder and director of a new course at Harvard Medical School, termed "Blood vessels and Endothelial Phenotypes in Health and Disease", and founder and first chairman of the bi-annual Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease. He has recently edited an introductory book on the endothelium that is in press at Marcel Dekker, and he is currently editing a definitive 2000 page encyclopedia on endothelial biomedicine. He received his medical degree from the University of Western Ontario in 1985. After completing his internal medicine and chief medical residency at the University of Toronto, he undertook a Hematology fellowship at the Brigham and Women s Hospital, Harvard Medical School. Dr. Aird received his postdoctoral training in Robert Rosenberg s laboratory at the Massachusetts Institute of Technology.

Directions:
The Bossone Research Enterprise Center is located on Market Street, between 31st and 32nd Streets. The auditorium is on the first floor.

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