Masters Thesis Defense - Bioceramics: An Overview of Existing Materials and a Proposed Next Generation Composite of Calcium Phosphate Cement and Demineralized Bone
Date: May 25, 2004
Time: 3:00 PM
Location: LeBow Engineering Building, Room: 348
Frank Ko, PhD (advisor)
Over one million operations per year involve bone repair, and in many of these cases, bone graft is required to augment healing. Numerous synthetic bioceramic materials have been used clinically in an attempt to augment or even replace autograft, with varying rates of success. Although these materials have been proven beneficial in various surgical indications, there are numerous opportunities for improvement. For example, the gradual adoption of calcium phosphate cements by the surgical community has been slowed by concerns over healing rates.
Thus, it has been proposed to add an additional biologically active agent to a calcium phosphate cement, such as demineralized bone (DBM). Material properties such as compressive strength, setting time, injectability, and mineralogy are characterized over a range of demineralized bone content (wt. %). The biologic effect of the inclusion of demineralized bone is characterized in vitro by soaking the material in simulated body fluid for fixed periods and examining the surface via EDAX. Variations in calcium, phosphate, and carbon on the surface of the composite indicate the presence of exposed DBM, which may be beneficial for bone healing in vivo.
To the best of the author’s knowledge, this thesis represents the most comprehensive analysis of a DBM calcium phosphate composite to date.
The LeBow Engineering Building is located at the southwest corner of 31st and Market Streets.