Seminar - New Laboratory Results Using Deep Brain Electrical Stimulation for Epilepsy Seizure Prevention
Date: May 11, 2004
Time: 2:00 PM
Location: Center for Automation Technology (CAT), Room: 276
David L. Sherman, PhD
Department of Biomedical Engineering
Johns Hopkins University
In spite of new anticonvulsant drugs, greater than 15% of patients with recurrent seizures are diagnosed as having medically intractable epilepsy. Electrical stimulation of the vagus nerve and deep brain stimulation (DBS) of critical areas outside of the cerebral cortex have been thought of as promising alternatives or supplements to anti-epileptic drug therapy. Our laboratory has gathered evidence implicating the anterior thalamus (AN) in the brain as a key subcortical site mediating the expression of experimental seizures in an animal model of epilepsy. DBS of the anterior thalamus is effective in raising seizure threshold in a chemically induced seizure model in rats. Additionally, the NIH has launched clinical trials of AN DBS for intractable epilepsy. Still, little is known about the anticonvulsant mechanisms of electrical stimulation. In this seminar, we will examine alterations in neural activity resulting from DBS. These alterations include DBS-induced changes in local neurotransmitter release as well as modifications in cortical field potential activity.
David Sherman was born in Buffalo, NY. He received a BA in psychology from Columbia University, a BSEE degree from Florida Atlantic University and MS and PhD degrees from Purdue University (both in electrical engineering). Dr. Sherman did a post-doc at the Johns Hopkins University (JHU) Department of Biomedical Engineering. He went on to receive a Whitaker Postdoctoral fellowship and a McDonnell-Pew fellowship in Cognitive Neuroscience.
Dr. Sherman also helped establish a small startup biomedical instrumentation company in Baltimore, MD, named Infinite Biomedical Technologies, with the assistance of the NIH Small Business Innovation Research (SBIR) program. He is currently a Research Assistant Professor in the Departmen of Biomedical Engineering at JHU. His research interests include understanding epilepsy, deep brain stimulation, and neuroelectric and biomedical signal analysis for medical instrumentation.
The Center for Automation Technology (CAT) is located on the southwest corner of 31st and Market Streets.