• biomed

Published Papers

N. Teraphongphom, P. Chhour, J. R. Eisenbrey, P. C. Naha, W. R. T. Witschey, B. Opasanont, L. Jablonowski, D. P. Cormode, and M. A. Wheatley, Nanoparticle Loaded Polymeric Microbubbles as Contrast Agents for Multimodal Imaging, Langmuir, Oct. 2015.

L. Albala, U. K. Ercan, S. G. Joshi, J. R. Eisenbrey, N. Teraphongphom, and M. A. Wheatley, Preservation of imaging capability in sensitive ultrasound contrast agents after indirect plasma sterilization, International Journal of Pharmaceutics, 494(1):146–151, Oct. 2015.

M. Bloch, L. Jablonowski, E. Yavin, D. Moradov, I. Djavsarov, A. Nyska, M. Wheatley, and A. Rubinstein, Multi-modal detection of colon malignancy by NIR-tagged recognition polymers and ultrasound contrast agents, International Journal of Pharmaceutics, 478(2):504–516, Jan. 2015.

J. R. Eisenbrey, L. Albala, M. R. Kramer, N. Daroshefski, D. Brown, J.-B. Liu, M. Stanczak, P. O’Kane, F. Forsberg, and M. A. Wheatley, Development of an ultrasound sensitive oxygen carrier for oxygen delivery to hypoxic tissue, International Journal of Pharmaceutics, 478(1):361–367, Jan. 2015.

B. M. Johnson, J. A. Fraietta, D. T. Gracias, J. L. Hope, C. J. Stairiker, P. R. Patel, Y. M. Mueller, M. D. McHugh, L. J. Jablonowski, M. A. Wheatley, and P. D. Katsikis, Acute exposure to ZnO nanoparticles induces autophagic immune cell death, Nanotoxicology, 9(6):737–748 Aug. 2015.

NL. Francis, PM. Hunger, AE. Donius, BeW. Riblett, A. Zavaliangos, UGK. Wegst, MA. Wheatley, An ice-templated, linearly aligned chitosan-alginate scaffold for neural tissue engineering. J. Biomed. Mat. Res. 101(12):3493–3503, 2013

S. Paul, D. Russakow, T. Rodger, K. Sarkar, Mi. Cochran, M. Wheatley, Determination of the interfacial rheological properties of a PLA encapsulated contrast agent using in vitro attenuation and scattering Ultras. Med. Biol. 39(7):277–1291, 2013

M. Cochran, MA. Wheatley In vitro gene delivery with ultrasound triggered polymer microbubbles. Ultras. Med. Biol. 39(6):1102–1119, 2013

MA. Wheatley, M. Cochran Ultrasound contrast agents In special issue Imaging in Drug Delivery and Theranostics: J. Drug Del.. Sci. Tech., 23(1):57-72 2013

BW. Riblett, N L. Francis, MA. Wheatley, UGK. Wegst, Hierarchical Structures: Ice-Templated Scaffolds with Microridged Pores Direct DRG Neurite Growth. Adv. Funct. Mater. 22(23): 4920–4923 2012

MC. Cochran, J. Eisenbrey, T. Bustamante, M. Wheatley, In Vitro Characterization of Docetaxel Loaded Microbubbles for Ultrasound Triggered Drug Delivery. Pharm. Engi. 32:1-10 2012

MA. Wheatley, MC. Cochran, JR. Eisenbrey, KL. Oum Cellular Signal Transduction can be Induced by TRAIL Conjugated to Microcapsules, J Biomed. Mat. Res: Part A. 100A(10):2602-2611 2112

MA. Wheatley, JR. Eisenbrey, Polymeric Imaging Agents, In: Matyjaszewski K and Möller M (eds.) (2012) Polymer Science: A Comprehensive Reference, 9:529-545. Amsterdam: Elsevier BV

MC. Cochran, JR. Eisenbrey, MC. Soulen , SM. Schultz, RO. Ouma, SB. White, EE. Furth, MA. Wheatley Disposition of ultrasound sensitive polymeric drug carrier in a rat hepatocellular carcinoma model. Acad. Radiol. 18(11):1341-1348, 2011

NL. Francis, MS. Shanbhag, I. Fischer, MA. Wheatley, Influence of alginate cross-linking method on neurite response to microencapsulated neurotrophin-producing fibroblasts. J. Microencap. 28(5):353-362, 2011

MC. Cochran, J. Eisenbrey, RO. Ouma, M. Soulen, MA. Wheatley, Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery Int. J. Pharmaceut. 414(1-2): 161-170, 2011

JR. Eisenbrey, M. C. Soulen, and M. A. Wheatley, Delivery of Encapsulated Doxorubicin by Ultrasound-Mediated Size Reduction of Drug-Loaded Polymer Contrast Agents, IEEE Trans Biomed. Engi. 57:24-28, 2010

MS. Shanbhag, JD. Lathia, MR. Mughal, NL. Francis, N. Pashos, MP. Mattson, MA. Wheatley Neural Progenitor Cells Grown on Hydrogel Surfaces Respond to the Product of the Transgene of Encapsulated Genetically Engineered Fibroblasts. Biomacromol 11:2936-2943, 2010

AC. Boesteanu, NS. Babu, MA Wheatley ES. Papazoglou, PD. Katsikis Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus. Vaccine 29:314-322, 2010

C. Solis, F. Forsberg, and MA. Wheatley. Preserving Enhancement in Freeze-Dried Contrast Agent ST68: Examination of Excipients. Int. J. Pharm. 396:(1-2):30-38, 2010

WJ. Duncanson, K. Oum, JR. Eisenbrey, RO. Cleveland, MA. Wheatley MA, JY. Wong , Targeted binding of PEG-lipid modified polymer ultrasound contrast agents with tiered surface architecture. Biotech. Bioeng. 106:501, 2010

M.A. Wheatley, J. Lewandowski. Nano-sized ultrasound contrast agent: salting-out method. Mol Imaging.9(2):96-107, (2010)

C. Solis, F. Forsberg, M.A. Wheatley. Preserving enhancement in freeze-dried contrast agent ST68: Examination of excipients. Int J Pharm.396(1-2):30-38, (2010)

F. Forsberg, J.B. Liu, M. Patel, L. Liu, L. Lin, C. Solis, T.B. Fox, M.A. Wheatley. Preclinical acute toxicology study of surfactant-stabilized ultrasound contrast agents in adult rats. Int J Toxicol.29(1):32-39, (2010)

J.R. Eisenbrey, O.M. Burstein, R. Kambhampati, F. Forsberg, J.B. Liu, M.A. Wheatley. Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery. J Control Release.143(1):38-44, (2010)

W.J. Duncanson, K. Oum, J.R. Eisenbrey, R.O. Cleveland, M.A. Wheatley, J.Y. Wong. Targeted binding of PEG-lipid modified polymer ultrasound contrast agents with tiered surface architecture. Biotechnol Bioeng.106(3):501-506, (2010)

S.R. Sirsi, R.C. Schray, M.A. Wheatley, G.J. Lutz. Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides. J Nanobiotechnology.7:1, (2009)

J.R. Eisenbrey, P. Huang, J. Hsu, M.A. Wheatley. Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents. Ultrasonics.49(8):628-633, (2009)

J.R. Eisenbrey, J. Hsu, M.A. Wheatley. Plasma sterilization of poly lactic acid ultrasound contrast agents: surface modification and implications for drug delivery. Ultrasound Med Biol.35(11):1854-1862, (2009)

J.R. Eisenbrey, P.N. Huang, M.C. Soulen and M.A. Wheatley, Doxorubicin Loaded Contrast Agents for Ultrasound Triggered Drug Delivery: Importance of Process Parameters, Pharm. Eng. 28 (5), (2008)

J.R. Eisenbrey, O. Mualem Burstein, M.A. Wheatley, Effect of Molecular Weight and End Capping on Poly (lactic-co-glycolic acid) Ultrasound Contrast Agents, Polymer Eng. Sci. 48:1785–1792, (2008)

M.A. Wheatley, J.D. Lathia and K.L. Oum. Polymeric Ultrasound Contrast Agent Targeted to Integrins: Importance of Process Methods and Surface-density of Ligand. Biomacromol. 8(2):516-522, (2007)

M.A. Wheatley, F.Forsberg, K. Oum, R. Ro, D.El-Sherif Comparison of in vitro and in vivo acoustic response of a novel 50:50 PLGA contrast agent Ultrasonics 44:360–367, (2006)

M.A. Wheatley, F.Forsberg, N.Dube, M.Patel and B.E. Oeffinger Surfactant-Stabilized Contrast Agent on the Nano-Scale for Diagnostic Ultrasound Imaging, Ultrasound Med. Biol. 32(1):83-93, (2006)

C.A. Tobias, S.W. Han, J.S. Shumsky, D. Kim, M. Tumolo, N.O. Dhoot, M.A. Wheatley, I.Fischer, A. Tessler, and M. Murray. Alginate Encapsulated BDNF-Producing Fibroblast Grafts Permit Recovery of Function after Spinal Cord Injury in the Absence Of Immune Suppression, J. Neurotrauma 22(1):138–156, (2005)

B. E. Oeffinger, F. Forsberg, D. A. Merton, M.Patel J. B. Liu, M. A. Wheatley, Design and Acoustic Characterization of a Nano-Scale Ultrasound Contrast Agent, J. of Ultrasound in Med. 23(6):S 77 (2004)

M.A. Wheatley. Can Targeted Contrast Agents Fulfill Dr Ehrlich’s Dream Of A Magic Bullet? J. Ultrasound in Med. 23(6):S 82, (2004)

N.O. Dhoot, C.A. Tobias, I. Fischer and M.A. Wheatley. Peptide-Modified Alginate Surfaces as a Growth Permissive Substrate for Neurite Outgrowth J Biomed Mater Res 71A:191–200, (2004)

K. Murat, Aktas, B.Farouk, P. Narayan, and M.A. Wheatley. A numerical study of the generation and propagation of thermoacoustic waves in water, Physics of Fluids 16 (10):3786-3794, (2004)

J.D. Lathia, L. Leodore, M.A. Wheatley. Polymeric Contrast Agent with Targeting Potential. Ultrasonics, 42 (1-9):763-768, (2004)

B.E. Oeffinger, M.A. Wheatley. Development and Characterization of a Nano-scale Contrast Agent Ultrasonics, 42 (1-9):343-347 (2004)

J.D. Lathia, D. El-Sherif, N.O. Dhoot, M.A. Wheatley. Surface Modification of Polymeric Contrast Agents for Cancer Targeting. Pharm. Eng. 24(1):1-8, (2004)

D.M. El-Sherif, J.D. Lathia, N.T. Le and M.A. Wheatley. Ultrasound Degradation of Novel Polymer Contrast Agents, J.Biomed. Mat. Res. 68A:71-78, (2004)

F. Forsberg, J.D. Lathia, D.A. Merton, J. Liu, N. Le, M. Shimizu, B.B. Goldberg and M.A. Wheatley. Effect of Shell Type on the In Vivo Backscatter from Polymer Encapsulated Microbubbles. Ultrasound Med Biol., 29(5) Suppl. 1:S96, (2003).

D. El-Sherif and M.A. Wheatley Development of a novel method for synthesis of a polymeric ultrasound contrast agent. Journal of Biomedical Materials Research 66A:347-355 (2003)

N.O. Dhoot and M.A. Wheatley, Microencapsulated Liposomes in Controlled Drug Delivery: Strategies to Modulate Drug Release and Eliminate the Burst Effect" J Pharm Sci 92(3): 679-89. (2003)

R. Basude and M.A. Wheatley, Generation of Ultra-harmonics in surfactant-based Ultrasound Contrast Agents- Use and advantages, Ultrasonics 39, 437-444 (2001)

P. Narayan, D. Marchant and M. A. Wheatley, “Optimization of spray drying by factorial design as a technique to produce hollow microspheres for ultrasound imaging”, J. Biomed. Mat. Sci. 56 333-341 (2001)

C.A.Tobias, N.. Dhoot, M. A.Wheatley, A. Tessler, M. Murray, and I. Fischer, Grafting of encapsulated BDNF-producing fibroblasts into the injured spinal cord without immune suppression in adult rat J. Neurotrauma. 18(3): 287-301 (2001)

M. Wheatley, “Composition of contrast microbubbles: Basic chemistry of encapsulated and surfactant coated bubbles” In Ultrasound Contrast Agents: Basic Principles and Clinical Practice, Second Edition, edited by B. Goldberg, J. Raichlen and F. Forsberg , Martin Dunitz, London, in press

R. Basude, J. Duckworth and M.A. Wheatley, “Influence of environmental conditions on a surfactant-stabilized contrast agent:ST68”, Ultrasound in Med. and Biol 26(4) 621-628 (2000)

P. Narayan and M. A. Wheatley, Preparation and Characterization of Hollow Microcapsules for use as Ultrasound Contrast Agents. Polymer Eng. and Sci.. 39 (11):2242-2255 (1999)

W. Shi, F. Forsberg, A. Hall, R. Chiao, J-B Liu, S. Miller, K. Thomenius, M. Wheatley and B. Goldberg, “Subharmonic Imaging with Microbubble Contrast Agents: Initial Results, Ultrasonic Imaging 21:79-94 (1999)

F. Forsberg, R. Basude, J. B. Liu, J. Alessandro, W. T. Shi, N. M. Rawool, B. B. Goldberg, M. Wheatley: “Effect of Filling Gasses on the Backscatter from Contrast Bubbles: Theory and in vivo measurements” Ultrasound in Biol. and Med. 25(8):1203-1211 1999

M.A. Wheatley, D. El-Sherif, R. Basude, R. Shimp amd P. Narayan, “Ultrasound-Triggered Drug Delivery with Contrast Imaging: Effect of Microencapsulation Method” In. Biomedical Materials-Drug delivery, Implants and Tissue Engineering, ed. Thomas Neenen, M. Marcalongo and R. Vlentini, MRS Symp. Proc. 550:113-117 (1999)

M.A. Wheatley and P. Narayan, “Diagnostic Use of Microcapsules”, in Encyclopedia of Controlled Drug Delivery. E. Mathiowitz Ed. CRC Press Baton Rouge, FL. 1999, pp313-340

N. Dhoot and M. A. Wheatley. "Microencapsulated Liposomes: An Approach to Controlled Drug Delivery" Bioencapsulation VII, Easton, MD (1998)

M. A. Wheatley, J. Alessandro, F. Forsberg, B. B. Goldberg and W. Wang: “Development of a new Surfactant-based Ultrasound Agent” Proc. of AAMI 97, AAMI, Arlington, VA, pp. 58, (1997).

M. Wheatley, F. Forsberg, N. M. Rawool, W. T. Shi, J. Alessandro and B. B. Goldberg: “Harmonic and Conventional US Imaging with SF6 Filled Microbubbles” Radiology, 205(P):417, (1997)

W. T. Shi, F. Forsberg, M. Gupta, J. Alessandro, M. A. Wheatley, and B. B. Goldberg: “Subharmonic Response of a New US Contrast Agent” Radiology, 205(P):353, (1997).

F. Forsberg, Y. Wu, I.R.S. Makin, W. Wang and M. A. Wheatley, “Quantitative acoustic characterization of a new surfactant based ultrasound contrast agent”. Ultrasound in Med. and Biol. 23 (8):1201-1208, (1997)

M. Gupta, W. T. Shi, J. Alessandro, F. Forsberg, Y. Wu, R. Bandue and M. A. Wheatley: Harmonic Properties of a New Surfactant Based Ultrasound Contrast Agent. Ultrasonic Imaging, 19(1):81, (1997).

F. Forsberg, J.B. Lui, D.A. Merton, W. Wang, M.A. Wheatley and B.B. Goldberg: Air-filled versus Perfluorocarbon-filled microbubbles for US contrast. Radiology, 201(P):153, (1996)

M. A. Wheatley, I. Makin, F. Forsberg, Y. Wu and W. Wang, "Development and Characterization of a New Diagnostic Contrast Agent" Medical Physics 23, (6), pp. 1061 (1996).

Wenhua Wang, Chris Moser and Margaret A. Wheatley, "Langmuir Trough Study of Surfactant Mixtures used in the production of a New Ultrasound Contrast Agent Consisting of Stabilized Microbubbles" J. Phys. Chem. 100(32)13815-13821, (1996)

F. Forsberg, N. M. Rawool, D. A. Merton, J. B. Liu, W. Wang, P.Kankate, J. Alessandro, B.B. Goldberg and M.A. Wheatley: Comparison of Air and Perfluorocarbon Filled Microbubbles for

Ultrasound Contrast Studies. Proc. IEEE Ultrason. Symp., M. Levy, S. C. Schneider & B. R. McAvoy (eds.),IEEE, New York, 2, pp. 1337 - 1340, (1996).

Margaret A. Wheatley, Linda Schadler and Banu Onaral “The GOES Project: A successful Outreach Program that Introduces Girls to Engineering” Proc. of Women in Engineering Conference, ‘Capitalizing on Todays Challenges’, Denver Co. June 1-4 pp 233-238 (1996)

Raj Mutharasan, Wayne Magee, Margaret Wheatley and Young Lee, "Thematic Introduction to Engineering Biotechnology: Gateway Experiences" Proc. Ann. Conf. ASEE. Anaheim, California, June 25-28 1995

M.A. Wheatley and S. Singhal, "Structural Studies on Stabilized Microbubbles: Development of a Novel Contrast Agent for Diagnostic Ultrasound" Journal of Reactive Polymers 25:157-166 (1995)

F. Forsberg, Y. Q. Wu., I. R. S. Makin, J. Srinivasan, W. Wang and M.A. Wheatley: In vitro and in vivo characterization of a new surfactant stabilized ultrasound contrast media. Proc. IEEE Ultrason. Symp., M. Levy, S. C. Schneider & B. R. McAvoy (eds.), IEEE, New York, 2: 1129 -1132, (1995)

T. Feeser and M.A. Wheatley ""Microencapsulated Liposomes: Lipid Stability and Influence of Entrapped Species " Proceed. Intern. Symp. Contol. Rel. of Bioact. Mater. 21 (1994)

M.A. Wheatley, D. Alford and C-Y S. Hsiao, "pH-Dependent pore formation in liposomes: An approach to triggered Release" Proceed. Intern. Symp. Contol. Rel. of Biocat. Mater. 21 (1994)

V.L. Newhouse and M.A. Wheatley edit. Special issue IEEE transactions on Ultrasonics, Ferroelectronics and Frequency Control 41(1):67-160 (1994)

S. Singhal, C.C. Moser and M.A. Wheatley, "Surfactant-stabilized Microbubbles as Ultrasound Contrast Agents: Stability Study of Span 60 and Tween 80 mixtures Using a Langmuir Trough" Langmuir. 9:2426-2429, (1993)

Teresa Feeser and M.A. Wheatley, "Pulsatile Drug Release From Polymeric Microcapsules" Proc. 20th Symp. on Controlled Release of Bioactive Materials, Washington, D.C. 20 Ed. T. J. Roseman , N.A. Peppas and H.L. Gabelnick, pp32-33 (1993).

M.A. Wheatley, Peng Shen, Shruti Singhal and Beth Schrope, "Biomedical Aspects of Ultrasound Contrast using Polymeric Microspheres" Polymeric: Materials Science and Engineering 66:93-94, (1992)

Beth Schrope, Peng Shen and Margaret A. Wheatley "Polymeric Systems for Diagnostic Ultrasound Contrast Agents" pp 371-384 in Cosmetic and Pharmaceutical Applications of Polymers, C.G. Gebelein Ed. Plenum Publishing Corp., New York. (1991)

M.A. Wheatley and R. Langer, "Coated Alginate Microspheres: Factors Influencing the Controlled Delivery of Macromolecules. J. Appl. Poly. Sci. 43:2123-2135, (1991)

P. Shen, Schrope B and M.A. Wheatley. "Polymer coated Microbubbles: A Novel Contrast Agent for Diagnostic Ultrasound" Polymer Preprints, 31(1):228, (1990)

M.A. Wheatley, Schrope B., and Shen P. "Contrast Agents for Diagnostic Ultrasound: Develop-ment and Evaluation of Polymer Coated Microbubbles" Biomaterials, 11(9):713-717, (1990).

M.A. Wheatley, Schrope B., and Shen P. "Polymeric Systems for Diagnostic Ultrasound" Polymeric: Materials Science and Engineering 63:144-7 (1990).

P.G. Kibat, Y. Igari, M.A. Wheatley, H.N. Eisen and R. Langer, "Enzymatically Activated Microencapsulated Liposomes can Provide Pulsatile Drug Release" FASEB 4, 2533-2539 (1990)

P. Shen, B. Schrope and M.A. Wheatley, "Polymer-Coated Microbubbles: A Novel Contrast Agent for Diagnostic Ultrasound" Polymer Preprints 31(1):228, (1990).