M.S., Mechanical Engineering, 2007, Villanova University
It is the desire of Pat to at the time of finishing his research to obtain a better understanding of the pathway which begins with some sort of stimulation which kicks of numerous signaling responses and culminates in vasodilatation within the human microvasculature. In order to do so Pat has been making
use of computational models to explore the transition from mechanical stimuli to chemical signaling as well as the influence of mass transfer and fluid dynamics on vasodilatation. The main molecules which his research is interested in include: nitric oxide, calcium, and cyclic guanosine monophosphate. The influence of shear stress and the means by which it produces signals within the endothelial cells is also a chief interest in his studies. It is his hope that by obtaining this better understanding of the mechanism
involved in this response new therapies can be developed which can aid in combating the various cardiovascular issues prevalent in today’s society.