Medical ultrasound refers to the use of high-frequency acoustic energy
for the purpose of medical diagnosis, monitoring, therapy, and investigation.
Today, medical ultrasound finds widespread use in cardiology, for the assessment
of a valvular stenosis, myocardial motion, and, most recently, cardiac blood
flow. The use of ultrasound in obstetrics has expanded to a point where
now between one-third and one-half of all pregnant women in the United States
receive one or more ultrasound examinations.
Many of the larger organ systems of the body can be effectively imaged
with ultrasound, for the detection of cysts, tumors, calcifications, tissue
abnormalities, and changes in size. The organs most commonly examined with
ultrasound are the liver, kidney, pancreas, breast, and uterus. In recent
years, ultrasound has also become a most valuable tool in ophthalmic examinations.
Conditions such as detached retina, tumors of the eye, and bleeding and
foreign bodies in the eye are easily detected.
Ultrasound is not only well established for diagnostic use, but has found
extensive use in diathermy for deep tissue heating in situations such as
arthritis, muscle injury and inflammation, and tendinitis. In the last few
years another therapeutic application of ultrasound has been implemented
clinically, in extracorporeal shock wave lithotripsy--a medical procedure
using focused sound waves to fragment kidney and gallbladder stones, without
the need for surgery.
- Ultrasound image processing
- Tissue characterization
- Modeling of ultrasonic bonders for quality monitoring
- Angular spectrum method to characterize propagation in inhomogeneous
- Transducer materials and characterization
- Estimation of beam-flow angle from Doppler spectrum
- Flaw detection
- Ultrasonic bubble sizing and fluid pressure measurement
- Direct and inverse problems in lossy acoustic media
- Early diagnosis of breast cancer using Doppler/B-mode ultrasound
- Early detection of breast cancer by Time Delay Spectrometry ultrasound
- Noninvasive characterization of atherosclerotic plaques
- Flow measurements
- Nonlinear acoustics
- Physical aspects of lithotripsy
- Shock wave sensors for noninvasive kidney- and gallstone fragmentation
- Evaluation and development of ultrasound contrast agents
The faculty contact person for this program is Peter A. Lewin, Ph.D.
Activities in the biomaterials area at Drexel have been part of the Biomedical
Engineering and Science Institute since its beginning. Recently biomaterials
research has expanded to include fibrous materials and the various prosthetic
devices requiring the use of both synthetic and natural fibers.The national
trend is for emphasis on improved materials performance and design. Some
of the new fields of investigation are micro tissue characterization and
evaluation, macromolecular drug release, three-dimensional fiber-reinforced
composites, and material surface modification.
- Controlled insulin delivery system
- Fiber-reinforced composites for bone fixation plates
- Composites for dental tooth-root implants
- Dental restorative composites
- Impedance measurements for tissue-implant biocompatibility
- Blood-biocompatible polymeric coatings
- Composite material damage assessment
- Corrosion detection in adhesively bonded structures
- Artificial ligaments
- Orthopedic cast
- Finger joint prosthesis
The faculty contact person for this program is Frank K. Ko, Ph.D.
Biomechanics is a broad area encompassing all disciplines in which mechanical
principles are applied to the understanding and acquisition of scientific
knowledge relating to the function of the human body. It includes, for example,
orthopedic biomechanics, in which this knowledge is applied to develop orthopedic
devices such as endoprostheses, fracture fixation devices, and artificial
ligaments, as well as to develop improved surgical procedures. Another branch
of biomechanics is the development of aids for the handicapped, recently
identified by NSF as an emerging area of national importance and expected
to receive increased attention and federal funds in the near and long term.
Rehabilitation engineering is another important branch of biomechanics.
Its major aim is to improve, through the application of engineering principles,
the rehabilitation process of the handicapped individual.
An important emphasis of the activity in biomechanics is that research
must be highly relevant to the clinical community. This is reflected in
the close ties established between the program and major hospitals, medical
schools, and health care industries in the area.
- The stabilizing role of human ankle and subtalar ligaments
- The effect of Achilles tendon lengthening on the passive and active
properties of the human
- ankle joint
- Investigation of the optimal load bearing characteristics of the patellar
tendon in P.T.B.
- Application of inverse optimization methods for the identification
of the governing principle
- of voluntary human arm motion coordination
- Development of a control strategy for whole arm prostheses and robotic
The faculty contact person for this program is Rami Seliktar, Ph.D.
|Cardiovascular Dynamics and Instrumentation|
Studies of the cardiovascular system and its diseases have historically
been a significant part of the research effort of the Biomedical Engineering
and Science Institute. A prime reason for this interest is the great benefit
that progress in this research area can provide to the quality of life of
individuals and to our national economy. At present, it is estimated that
more than 35 million Americans suffer from some type of cardiovascular disease.
Over one-half of all deaths in the United States are attributable to cardiovascular
problems, and over 20 percent of those deaths occur before age 65, during
the most productive life period. In 1979, it was estimated that cardiovascular
mortality, and the loss of production due to this type of illness, cost
the nation's economy $81.3 billion.
Although cardiovascular research attracts many investigators, the Biomedical
Engineering and Science Institute possesses several advantageous features
found in few other research centers. Since its inception, the Institute
has used a balanced (engineering and medical) approach in its research.
The program's interdisciplinary nature makes it possible to bring a wide
spectrum of interests and expertise to bear on research problems. This is
especially appropriate for cardiovascular research, where many branches
of engineering and life sciences must be employed to provide practical solutions
to problems. The interdisciplinary nature of the program also attracts a
wide range of students. The mix of students with backgrounds in life sciences,
engineering, and clinical and allied health professions provides a synergism
not found in traditional engineering or medical programs.
In addition, the proximity of Drexel to the fine medical schools, hospitals,
and biomedically related industry of the area provides great opportunities
- Modeling of the cardiovascular system
- Cardiovascular dynamics
- Cardiovascular instrumentation
- Noninvasive evaluation of cephalic blood flow in the high-G environment
- Use of external pulsations to increase tolerance to acceleration stress
- Control of cardiac assistance devices
- Innovative techniques for noninvasive continuous blood pressure monitoring
- Coronary circulation
- Assessment of cardiac function
The faculty contact person for this program is Dov Jaron, Ph.D.
|Medical Imaging and Image Processing|
This field deals with the production and automatic interpretation of
images that arise in medicine and in biomedical research. Medical imaging
techniques include computed tomography, nuclear magnetic resonance imaging,
and real-time ultrasonography. Devices for the automatic karyotyping of
human chromosomes are an example of clinical application of machine interpretation
. Among the diverse research applications are isotope tracer and fluorescent
labeling techniques that are vital in the study of the structure and function
of living organisms.
The Biomedical Engineering and Science Institute has established a track
record in general image processing and in diagnostic ultrasound. A Biomedical
Technology Center in autoradiographic image processing, funded by NIH, was
established here in 1984. The increasing role of medical care in the national
economy, coupled with federal recognition of the importance of biological
imaging, implies that research and development in the field will continue
- Quantitative analysis of shape applied to visual images
- Signal processing schemes for target extraction and automatic clutter
rejection in radar
- Inverse acoustical scattering
- Model-based image analysis of medical images
- Center for Biomedical Imaging
The faculty contact person for this program is Jonathan Nissanov, Ph.D.
|Computer Applications to Health Care|
Although there has been much technological advancement in medical care,
a major limitation has been in the delivery of its benefits to the public
in an expeditious and economical manner. A large portion of the high-tech
aspect of health care delivery takes place in the hospital, an environment
conducive to high cost, tedium, contagion, and--unless its special facilities
are needed--inefficiency. Before the tendency to centralization of health
care delivery, the care of a child with an acute sore throat and fever usually
involved a prompt, comforting visit, at home, by the family doctor, at a
cost of a few dollars. Today the same problem might be met by a visit to
a hospital emergency room in a milieu of noise (even physical violence),
treatment by persons unfamiliar to the family, delay, confusion, and outrageous
expense. More recently there has been a trend toward returning medical care
to the home. There is, however, a great deficit in our ability to provide
diagnostic, therapeutic, and educational health services in a decentralized
setting. The ability to provide definitive health care in the home will
mean great savings in terms of safety and convenience, as well as in time
Among the particular criteria for health care delivery in the noncentralized
environment are noninvasiveness, and simplicity and objectiveness of operation,
in addition to the conventional requirements of safety and effectiveness.
Other important issues include the ethical, legal, financial, social, and
educational aspects of such technology transfer. These considerations impose
the need for intensive multidisciplinary study in addition to engineering
innovation.We are currently utilizing modern computer technology to address
the above concerns in some specific areas.
- Deamination burden as a parameter of diet planning
- Computer-aided diet planning
- Microcomputer support of home health care
- Center for Computing in Health Care
- Expert/Advisory systems for statistical consulting
- Technical and quantitative support of laboratory animal resources
- System validation for the pharmaceutical industry
The faculty contact person for this program is Stephen Dubin, Ph.D.
|Biomedical Signal Processing|
The research in biomedical signal processing includes several areas of
current interest in the biomedical field aimed at the extraction of features
for pattern recognition and noise reduction. Various techniques from estimation
and detection theories are used to reduce noise and to producebetter wave
forms. Principles and techniques of digital signal processing, communications,
and pattern recognition are applied to the acquisition, storage, and analysis
of biological signals, with emphasis on electroencephalograms and electrocardiograms.
One of the main focuses of our research is data reduction techniques coupled
with methods of directly processing the compressed signals without loss
of clinical information. Another important application of signal processing
is in understanding of the basic mechanisms of pathophysiological events
generated by signals. For example, efforts are underway to quantitate cardiac
late-potentials in order to identify patients prone to life-threatening
- Methods for detection of high-G blackout by digital signal processing
of the EEG
- Database reduction and processing techniques for electrical activity
maps of the brain
- Advanced signal processing of gastrointestinal signals
- Automatic compensation for the distortion in clinical blood-pressure
- Interpretive Holter ECG analysis and data compression for digital storage
- Detection of life-threatening cardiac arrhythmias using time-frequency
- ventricular complexes
- Analysis of exercise stress ECG
- Source localization in neuromagnetometry and evoked potentials
|Neural Networks and Systems|
The area of neural systems encompasses those research activities dealing
with sensory and motor aspects of living organisms. Research may involve
modeling of neurophysiological and neuropsychological phenomena or the application
of the knowledge of living neural systems to nonliving devices such as robots
or computers (neural networks).
The emphasis of the biomedical engineering neural systems program is
on the control of biological processes. Current projects include determining
the interaction of the cervico-ocular reflex and the vestibulo-ocular reflex
in their effects on posture and locomotion; modeling the attentional control
of behavior and learning; implementing mixed rule base and neural network
architectures using object-oriented style programming; the effect of norepinephrine
depletion on the relearning of motor tasks; and models of automaticity.
- Biomechanical and EMG correlates of step-down in humans
- The effect of norepinephrine depletion on the relearning of motor tasks
- Cervico-ocular reflex and vestibulo-ocular reflex effects on eye stability
- Neural network description of plasticity in motor systems
- Modeling attentional control of behavior with a hierarchal neural network
- Implementing mixed rule base and neural network architectures using
- Modeling attentional control of learning with a hierarchal neural network
- Models of automaticity
- Neural networks in signal processing
- Cognitive psychophysiology correlates from evoked magnetic fields and
- Neural network processing of evoked magnetic fields and evoked potentials
- Computational modeling of neural mechanisms for control of respiration and locomotion
The faculty contact person for this program is Allon Guez, Ph.D.
Biophysics is a branch of physics concerned with living organisms. The
goal of biophysics is to explain biological events in terms of physical
laws and principles. Biophysics uses the tools and concepts of the physicist
and mathematician to define and approach biomedical problems.
- Dynamics of biomolecules
- Laser-induced temperature jumps in single muscle fibers
- Laser photolysis of caged compounds
- Study of muscle cross-bridge kinetics using synchrotron radiation
- Phase Transitions in Biomembranes
The faculty contact person for this program is Frank Ferrone, Ph.D.
The research in sensory systems is related to the principles and techniques
of biomedical engineering in a number of ways. First, electronic information
processing and optical procedures may be developed and employed to evaluate
normal sensory function, as well as the diagnosis of pathologies involving
sensory systems. Second, biomedical engineering is intimately involved in
the development of assist devices which may be employed when sensory function
is impaired by disease or genetic defects, as well as in normal losses of
sensory function which accompany aging. Third, the techniques of biomedical
engineering may be employed to evaluate the effects of environmental stress
on sensory function, such as those encountered in the military, e.g. the
effects of G forces on sensory function. In addition to these numerous and
more obvious applications of xbiomedical engineering, sensory receptor systems
have achieved remarkable sensitivity, dynamic range, and temporal and spatial
resolution. An interesting example of the evolutionary development is the
ability of the dark-adapted rod photoreceptor to function as a single photon
detector. An understanding of the principles by which sensory systems detect
and process information may lead to the application of such principles to
the development of man-made detectors and information processing devices.
In this case the role of biomedical engineering would be that of mimicking
nature in its extraordinary capacity to detect and process information about
- Mechanisms of retinal blood flow regulations
- Coupling of oxidative metabolism to function in vertebrate photoreceptors
- Roles of retinal arrestin in signal transducing systems
The faculty contact person for this program is Bahram Nabet, Ph.D.
|Cartography and Brain Mapping|
The faculty contact person for this program is Jonathan Nissanov, Ph.D.
Many drugs, such as vaccines, hormones and some antibiotics, require a delivery
regime which is not zero order, for example vaccines need to be administered in pulses
with time intervals between the pulses varying from a few weeks to months, while the
hormone insulin needs to be delivered in response to elevated blood glucose levels.
We approached this problem by combining two established technologies, liposomal
entrapment of drug, and microencapsulation, to develop an entirely new modality,
microencapsulated liposomes. This allows us two control points. No drug will be
delivered until it is first released from the liposome, and once it is released the
rate at which it is delivered to the body can be controlled by a rate controlling
membrane on the microcapsule. The system also offers the advantage that the liposomes
are protected from the immune system, and therefore are not taken up and delivered to
the liver and spleen, and are also protected from phospholipid exchange that could
occur if they were in the blood stream.
Liposomes are self assembling vesicles, in the nanometer to micron size range,
composed of a bilayer of phospholipid molecules. The size and structure are
determined by the method of preparation. When the liposomes form they entrap a
portion of the aqueous environment, and if a drug, such as insulin, is dissolved in
that aqueous medium then that will become entrapped.
We have chosen to make microcapsules by ionotropic gelation of the naturally
occurring polymer, alginate. When an aqueous solution of sodium alginate is sprayed
into calcium chloride solution, the drops gel upon contact with the calcium ions in
the solution. If drug-containing liposomes are suspended in the sodium alginate
before spraying, then they will become encapsulated. A rate-controlling membrane of
a polycation such as poly-L-lysine can be coated on the microcapsules by simple
contact with a polymer solution. This aqueous, mild microencapsulation method is
ideal for encapsulation of sensitive structures such as liposomes. The size of the
capsules can be controlled form about 50 µm to over 500 µm by the method of spraying.
As liposomes age they become leaky. We have developed a system of encapsulated
liposomes, which will release their contents at different time points, depending on
the composition and type of liposome. In this way, if a cocktail of liposomes is
encapsulated, drug could be released in a series of pulses.
Management of diabetes requires delivery of exogenous insulin, preferably in
response to elevated blood glucose levels. In the literature, we have found an
amphipathic polymer, polyethyl acrylic acid (PEAA) that has been developed by Dr.
D. Tirrell at the University of Massachusetts, which changes conformation and
hydrophobicity with pH. At low pH the polymer adopts a globular hydrophobic
conformation which interacts with the liposome bilayer causing it to become leaky.
We have shown that the rate and extent of leakage can be controlled by the pH and
the liposome to PEAA ratio. We are developing a responsive capsule which will contain
liposomes loaded with insulin, PEAA and immobilized glucose oxidase enzyme(GOD).
The scenario which we envision is that glucose will diffuse into the capsule, react
at the GOD, the resulting gluconic acid will lower the pH, the PEAA will become
protonated, change conformation and disrupt the bilayer, insulin will be released,
pass out of the capsule, lower the glucose levels, the pH will re-equilibrate with the
physiological pH of 7.4 and the leakage of insulin will cease.
Depending on the temperature, phospholipids in a membrane can be in either a gel
or crystalline phase. The temperature at which they pass form one phase to another is
called the phase, or glass transition temperature (Tm). Different phospholipids have
different phase transition temperatures, and liposomes become leaky as they pass
through the transition temperature of their constituent liposomes. We are investigating
the use of temperature to induce leakage in encapsulated liposomes as a method of
drug delivery to areas of elevated temperature such as tumors, inflammation and
- Development of pulsed and triggered release systems
- Pulsed system for vaccines
- Triggered system for Insulin delivery
- Temperature sensitive liposomes for pulsed release
The faculty contact person for this program is Margaret Wheatley, Ph.D.
Call For Proposals
Develop and Deliver scientific information and technology that maximizes elite athlete performance to appropriate coaches and athletes by:
- Collaboration with USOC Member Organizations, the science and technology community and the USOC,
- Facilitating the collaboration of the science and technology community, coaches, athletes and Member organizations and
- Funding research and development that answers critical performance questions in sport.
To Request Sport Science & Technology Grant Guidelines
A complete set of the grant guidelines is available at this website
Call (719) 578-4793
You will reach a voice mailbox. Leave your name, address and daytime phone number. Please spell out your name and street and city names.
Grant Guidelines Request
Sport Science & Technology U.S. Olympic Committee
One Olympic Plaza
Colorado Springs, CO 80909
Research Facilities and Environment
Multidisciplinary research is carried out through a collaboration between
faculty members from different fields at the University as well as through
collaboration with several medical schools and hospitals in the Philadelphia
area. The School of Biomedical Engineering, Science and Health Systems
operates core research and computing laboratories for both educational
and research purposes. The School also operates the Calhoun Comparative Medicine
Laboratories, which are Drexel's central facilities for the care and use
of laboratory animals. The laboratories occupy about 7,000 square feet
in the modern Lebow Engineering Center. Facilities are available for sterile
surgery, radiography, and other research procedures. Networked computing
equipment includes a number of workstations, including Sun Enterprise and
SPARC stations, Silicon Graphics Systems, and a number of personal computers
including Apple Macintosh and IBM-compatible computers. In addition to
the core facilities, laboratories designed for specific research projects
are operated by individuals or by teams of faculty members. These laboratories
provide facilities for research in artificial organs, biocontrol systems,
bioelectrochemistry, bioelectrodes, biomaterials, biomechanics, biomedical
imaging and signal processing, biosensors, biostatistics, cardiac assist
devices, cardiovascular systems dynamics, cell culture, chronobiology,
dental implants, diagnostic ultrasound, electrophysiology, modeling of
physiological systems, neural networks and systems, and rehabilitative
Biomedical Engineering Laboratory
Dr.Margaret Wheatley - Laboratory Director
The biomedical engineering laboratory is set up for research into controlled-release of drugs,
and for development of a novel ultrasound contrast agent. In addition to standard laboratory
equipment such as pH meters, rotary evaporator, bench centrifuge and analytical balances, this
facility includes a controlled environment incubator, Heat Systems probe sonicator, Laboratory
supplies bath sonicator, custom built ionotropic gelation apparatus, Packard scintillation
counter, and a Hitachi U2000 UV/visible scanning spectrometer with variable temperature cells
and accompanying computer for data acquisition and analysis.
Biomaterials research has recently expanded to include fibrous materials
and various prosthetic devices requiring the use of both synthetic and
natural fibers. The trend is toward the emphasis on improved materials
and design. Some of the new fields of investigation are the micro tissue
characterization and evaluation, macromolecular drug release, three dimensional
fiber-reinforced composites, and material surface modification.
The Biomaterials Laboratory facilities include diffusion cells for drug release measurements,
a polymerization facility, a thermal analysis facility for polymer characterization,
scanning and transmission electron microscopes, RF plasma reactor. Laboratory
extruder, two-ounce injection molding machine, hot press, rubber mill,
x-ray facility, and centrifugal casting machine.
Dr. Nihat Bilgutay - Laboratory Director
The Signal Processing Laboratory (SPL) facility features networked computer-based data acquisition, instrument automation and graphics capability
and incorporates a Sun SPARC 20, a number of personal computers, and an
HP 3562A Dynamic Signal Analyzer, a EG&G PAR 173 Potentiostat/Galvanostat.
Other general purpose laboratory equipment includes scopes, multimeters,
pulse and signal generators, power supplies and amplifiers.
Dr.Banu Onaral - Laboratory Director
The Scaling Signals and Systems Laboratory (SSSL) is a facility dedicated to the measurement, analysis,
and modeling of broadband distributed phenomena which 'scale', i.e., exhibit
systematic relationships between temporal and spatial scales. Research
projects in biomedical signal processing and system analysis exploit advanced
methods of multi-scale system theory as well as multi-rate and multi-resolution
signal processing techniques.
The Ultrasound Laboratories researchers use high frequency acoustic
energy for the purpose of medical diagnosis, monitoring, therapy and investigation.
Medical ultrasound is widely used in cardiography and obstetrics but is
also used in many other areas as well. the organs most commonly examined
with ultrasound are the liver, kidney pancreas, breast and uterus. Recently,
ultrasound has also become a most valuable tool in ophthalmic examinations
easily detecting conditions such as detached retina, tumors of the eye,
Dr. Athina P. Petropulu - Laboratory Director
The Communications and Signal Processing Laboratory located in Commonwealth Hall,
Room 707 is dedicated to research in statistical signal processing.
Some of the current projects are:
- communications (blind equalization);
- higher-order spectra analysis
(system identification, signal reconstruction, low-rank estimators of
- alpha-stable processes and relationship
with 1/f signals;
- ultrasound imaging (resolution improvement of
ultrasound image for breast cancer detection at early stages, attenuation
- earthquake engineering (site response analysis).
The lab currently serves 8 graduate students, and is established
through funding from the National Science Foundation, US Army, The Whitaker
Foundation, and support from Drexel University.
The lab is equipped with:
- SUN Ultra ENTERPRISE 2, Dual-200 MHz processors, 8.6 GB Hard Disk, 256 MB R
AM, Exabyte 8505/XL Tape Drive (6-14 GB), CD-ROM (internal), Floppy Disk
(1.4 MB internal), color monitor, Solaris 2.5.1.
- SUN Ultra 1, 147 MHz Processor, 2 GB Hard Disk Space, 64 MB RAM, color monitor, Solaris 2.5.1.
- SUN SparcStation 5, 110 MHz processor, 64 MB RAM, 1.2 GB Hard Disk, CD-ROM
(external), color monitor, Solaris 2.5.
- SUN SparcStation 5, 70 MHz processor, 64 MB RAM, 2.4 GB Hard Disk, color monitor, Solaris 2.5.
- Three (3) HDS @work Supra-66 17CH X-terminals, color monitor,
16 MB RAM.
- APPLE LaserWriter 16/600 PS
Drs. Oleh Tretiak and Jonathan Nissanov - Laboratory Directors
The Imaging and Computer Vision Center is located in Commonwealth Hall, Room 110.
ICVC pursues research in the
fields of imaging, computer vision, image processing, image pattern recognition,
and the extraction of quantitative data from images. Work is performed
in a number of application domains, with concentration on Biology and Medicine.
Laboratory: The Imaging and Computer Vision Center consists of both a computer
(about 1800 sq. feet) and an histology laboratory (about 250 sq. feet).
The computer laboratory is equipped with UNIX and Macintosh platforms. The UNIX computers
are: Silicon Graphics (4D220 and Personal Iris), SUN (4/260 and 4/110),
and PC compatibles. These computers are interconnected through Ethernet
to the campus network and INTERNET. The Macintosh computers are connected
through AppelTalk to a server and a bridge to Ethernet and INTERNET. Peripheral
equipment includes television cameras for image capture, color and monochrome
displays, document scanners (an Agfa Arcus 1200 DPI and an Apple 4-bit
scanner) and laser printers. Among other software, the lab has operating
systems and languages for program development, programs developed in house,
commercial image processing, display, graphics and word processing applications.
The histology laboratory currently has a custom-designed Leica Jung Cryopolycut
cryostat with mounted digital camera, a Hacker-Bright cryostat fitted with
a Instrumedics tape support system, a vibratome, 2 dissecting scopes (an
Olympus and an upright surgical Zeiss), 2 Zeiss microscopes including an
Axoplan, and the various small items necessary for histological processing.
Calhoun Laboratory for Comparative Medical Science
The Calhoun Laboratory for Comparative Medical Science is Drexel's
central facility for the care and use of warm blooded laboratory animals.
It occupies about 7000 sq. ft. in the modern Lebow Engineering Center.
Facilities are available for sterile surgery, radiography, and other research
procedures. Research laboratory space is provided to facilitate those projects
where investigators require rapid access to animals, their tissues or fluids.
Small Animal Chronobiology Laboratory
The Small Animal Chronobiology Laboratory is part of the Calhoun
facility and features environmental chambers capable of housing rodents
in controlled conditions. These chambers are sound-attenuated with individual
computer-controlled temperature and lighting. Computerized data acquisition
from running wheel activity using Nalge activity cages is possible 24 hours
per day for up to 1 year. In addition to these chambers, HEPA filtered
isolation units with controlled lighting for immunological experiments
with mice or hamsters are also available.
The Biomechanics Laboratory is equipped with anatomical dissection
facilities; kinematic data acquisition systems; instrumentation for measuring
joint flexibility, equipment for measuring acceleration, force and pressure.
The Occupational Biomechanics Laboratory is where biomechanical, ergonomic
and human factor aspects are studied with relation to injuries sustained
in the work environment. The laboratory has close ties with the Human Motion
Analysis Laboratory at Moss Rehabilitation Hospital. The Rehabilitation
Engineering Laboratory is concerned with the development of equipment needed
in the our research in the area of rehabilitation and aiding the handicapped.
The laboratory has a children's mobility trainer, computer interfaced prosthetic
arm, a variety of instruments for interfacial stress measurements in lower
limb prostheses and other universal force displacement measuring systems.
Research is going on in the following areas: limb prostheses, orthopedics
implants, mobility aids for handicapped children; augmentative communication
systems and other environmental control devices. Joint projects with the
Rehabilitation Robotics Laboratory at the A.I. duPont Institute in Delaware
are in progress. The research performed in the area of biomechanics is
highly relevant to the clinical community and therefore requires close
ties between the university and major hospitals, medical schools and health