Seminar - Tissue Informatics: Profiling, Correlation and Modeling
Date: February 14, 2003
Time: 3:00 PM
Location: LeBow Engineering Center, Room: 240
TissueInformatics, Inc., Pittsburgh, PA
Tissue specimens have been the primary source for medical diagnosis since the invention of the microscope. It is surprising to realize that despite the enormous progress in digital microscopy, the prevailing method to analyze tissues is done by visual inspection, both in clinical applications and pharmacological research. There are a number of technical barriers for a fully automated tissue analysis, such as time-efficient data acquisition of complete tissue sections, robust machine vision, and handling and mining of large image datasets. This presentation reports on recent progress made to develop a system that allows to carry out a comprehensive structural profiling of normal and disease tissue specimen. Beside a step forward toward to an objective diagnostic, this kind of tissue information can be combined and correlated with other digital data throughout the continuum of bioinformatics. New methods are presented that link gene expression data to tissue phenotypical structural data, which essentially is a step forward to supplement current gene-centric methodologies. Applications include drug target development and investigative toxicology. Another area of application is the use of tissue data for the development of hierarchical structural models of larger tissue constructs and organs that can be subsequently used to carry out functional simulations and serve as a blueprint for tissue engineering applications.
Andres Kriete studied Physics at the Universities in Bremen and Hamburg, Germany. He received his Ph.D. in digital image analysis in 1985. He also worked as a computer scientists at Kontron, Image Analysis Division, Munich, as a research associate at the University of Wuerzburg and was invited Visiting Professor at the University of Bremen, Institute of Complex Systems and Medical Visualization (CeVis/MeVis).
Andres Kriete was faculty member at the University Clinic Giessen and Head of the Image Processing Laboratory at the Institute of Anatomy and Cell Biology from 1987 to 2000. His focus was on multidimensional image analysis in microscopy and clinical research, computer graphics, visualization, in-silico biology including modeling of biological structures and functional simulation, multimedia databases, digital anatomical atlases, and computer guided surgery. He developed a functional computer representation of lung and received his venia legendi (Habilitation) in 1997 at the University Clinic Giessen. His work was appreciated by over 10 co-authored research grants. In 1988, he initiated an international annual series of conferences under the title of "Focus on Microscopy", being well recognized in the field of 3D microscopy and related technologies. He served as co-organizer and advisor within this series and emerging workshops. He teached over 15 courses and was invited faculty member to international courses on multidimensional imaging.
Andres Kriete published two books, has 21 papers in reviewed journals, and 35 papers in conference proceedings. He published 4 reviews and contributed 8 chapters to multiauthored books. He is member of the editorial board of several leading microscopical journals. Andres Kriete served various panels including ASTM, F04 on Tissue Engineered Medical Products and NIH BECON 2001 on functional assessment of engineered tissue.
Andres Kriete is currently Director of Imaging Sciences at TissueInformatics. Inc., Pittsburgh, and involved in R&D projects that include automated multidimensional imaging, image analysis, and bioinformatics to characterize tissues. Main applications are in drug target development and investigative toxicology. He is also Visiting Associate Professor, University of Pittsburgh.
The LeBow Engineering Center is located at the southwest corner of 31st and Market Streets.