Aydin Tozeren, Ph.D.
Director, Bioinformatics Program

School of Biomedical Engineering, Science & Health Systems, DrexelUniversity
Office: Commonwealth 7-605  Email: tozeren@coe.drexel.edu
Phone: 215.895.6148   Fax: 215.895.4983 

Biosketch:
Dr. Aydin Tozeren received his Ph.D. from Columbia University in 1974. Since then, he has published in the areas of cell adhesion and signaling, molecular basis of muscle contraction, biomechanics, and mathematical modeling of biological systems. Dr. Tozeren's book Human Body Dynamics: Classical Mechanics and Human Movement received the Best Engineering Title Award for the year 2000 by the Association of American Publishers. His upcoming book, New Biology for Engineers and Computer Scientists will be published by Prentice Hall and is presently in the production stage. Dr. Tozeren held academic and research positions at ColumbiaUniversity, the National Institutes of Health, and the Catholic University of America, where he served as the Chair of the Department of Biomedical Engineering. Dr. Tozeren received and directed research grants from the National Science Foundation, the National Institutes of Health, the Department of Defense Breast Cancer Research Fund, as well as a recent biomedical engineering infrastructure special opportunity grant from the Whitaker Foundation. Dr. Tozeren has taught a large number of graduate and undergraduate courses, guided doctoral dissertations, and in 1996, received the Alpha Delta Gamma Outstanding Teacher Award at the Catholic University of America. During the year 2001, he served as a member of the Board of Scientific Advisors of the Whitaker Foundation.

Research Keywords:
Breast cell adhesion and communication, signal transduction networks in cancer and epithelial cells, integrated bioinformatics, molecular profiling.

Education:
PH.D., Columbia University, Bioengineering concentration, 1974
M.S., Columbia University, Engineering mechanics, 1972
B.S., Orta Dogu Technical University, Ankara, TR, 1971

Books:

Human Body Dynamics: Classical Mechanics & Human Movement (1999), Aydin Tozeren,

Springer-Verlag, New York, NY.

New Biology for Engineers and Computer Scientists (2002),Aydin Tozeren and SW Byers, Prentice Hall, NJ (in production).

Journal Articles (since 1990):

1.       Tozeren, A., Cell-Cell Conjugation: Transient Analysis and Experimental Implications, Biophys. J., 58:641-652, (1990).

2.       Tozeren, A., Cell-Cell, Cell-Substrate Adhesion: Theoretical and Experimental Considerations, J. Biomech. Engr., 112:311-318, (1990).

3.       Tozeren, A., K.L.P. Sung, L.A. Sung, M.L. Dustin, P-Y. Chan, T.A. Springer and S. Chien, Micromanipulation of Adhesion of a Jurkat Cell to a Planar Membrane Containing either Mobile or Immobile LFA-3 Molecules, J. Cell Biol., 116:997-1006 (1992).

4.       Tozeren, A., L.H. Mackie, M.B. Lawrence, P-Y. Chan, M.L. Dustin and T.A. Springer, The Interaction of PMA-stimulated T Lymphocytes with Planar Membranes Containing Intercellular Adhesion Molecules, Biophys. J., 63:247-258 (1992).

5.       Tozeren, A. and K. Ley, How Do Selectins Mediate Leukocyte Rolling in Blood Vessels?, Biophys. J., 63:700-709 (1992).

6.       Tozeren, A., H.K. Kleinman, S. Wu, A.M. Mercurio and S.W. Byers, Integrin 64 Mediates Dynamic Interactions with Laminin, J. Cell Science, 107: 3153-3163 (1994).

7.       Tozeren, A., Cell Tumbling in Laminar Flow: Cell Velocity is a Unique Function of the Shear Rate.  Cellular Mechanics and Cellular Engineering, Ed. V. C. Mow, F. Guilak, R. Tran-Son-Tay, and R.M. Hochmuth., Springer and Verlag (1994).

8.       Tozeren, A., H.K. Kleinman, D.S. Grant, D. Morales, A.M. Mercurio, and S.W.Byers, E-Selectin-Mediated Dynamic Interactions of Breast and Colon Cells With Endothelial-Cell Monolayers, Int. J. Cancer, 60: 426-431 (1995).

9.       Ozerdem, B. and A. Tozeren, Collagen Gels Have Instantaneous Elasticity, ASME J. Biomechanical Engineering, 117: 397-402 (1995).

10.    Byers, S.W., C.L. Sommers, B. Hoxter, A.M. Mercurio, and A. Tozeren, The Role of E-Cadherin in the Response of Tumor Cell Aggregates to Lymphatic, Venous and Arterial Flow: Measurement of Cell-Cell Adhesion Strength, J. Cell Sci., 108: 2053-2064, (1995).

11.    Tozeren, A.  Biophysical Parameters of Leukocyte Adhesion to Vascular Endothelium, Physiology and Pathophysiology of Leukocyte Adhesion, Ed. D. Neil Granger and Geert W. Schmid-Schonbein, Oxford University Press, New York (1995). 

12.    Brooks, S. and A. Tozeren, Laminar Flow Past an Array of Cells That are Adherent to the Bottom  Plate of a Flow Channel, Computations and Fluids 25: 741 - 757 (1996).

13.    Byers, S.W., Pishvaian, M., Crockett, C., Peer, C., Tozeren, A., Sporn, M., Anzano, M., Leichleider, R., Retinoids Increase Cell-Cell Adhesion Strength, b-Catenin Protein Stability and Localization to the Cell Membrane in a Breast Cancer Cell Line: A Role for Serine Kinase Activity.  Endocrinology 137:3265-3274, (1996).

14.    Damiano, E.R., J. Westheider, A. Tozeren, and K. Ley, Variation in the Velocity, Deformation, and Adhesion Energy Densities of Leukocytes Rolling Within Venules, Circulation Research 79: 1122-1130, (1996).

15.    Wu, S., Hoxter, B. Byers, S.W., and A. Tozeren.  Role of Cytoskeleton and Deformability in Laminin-mediated Rolling. Biorheology 35: 37-51, (1998).

16.    Tozeren, A., Wu, S., Hoxter, B., Adamson, E.D., and S.W. Byers. Vinculin and Cell to Cell Adhesion.  Cell Adhesion and Communication 5: 49-59, (1998).   

17.    Avvisato, C. L., Hoxter, B., Gaynor,  R., Pestell, R., Tozeren, A., and S.W. Byers. Mechanical Force Modulates b-catenin Signaling Through Integrin α6β4 and the IκB kinase Complex. (2002). Manuscript in review.

Awards:

Alpha Delta Gamma Outstanding Instructor Award in 1996

Best Engineering Title for 2000 Award for Human Body Dynamics by the Association of American Publishers (http://www.pspcentral.org/).

Member, Acadamic Council, AIMBE.

Guest Member, Board of Scientific advisors, Whitaker Foundation.

Director, Whitaker Foundation Special Opportunity Grant, 1999-2002

Grants from NSF and NIH.

Collaborators & Other Affiliations

Collaborators in the Past 48 Months:

Dr. Stephen W. Byers, Professor of Molecular Cell Biology, Georgetown University
Dr. Klaus Ley, Professor of Biomedical Engineering, University of Virginia

Ph.D. Advisor:

The late  Richard Skalak, James Finch Kipp Professor at Columbia University and
Professor in Residence at the University of California, San Diego.

Graduate Students and Post-doctor Fellow Advising:

1) Chris Avvisato (2002), Thesis: Effect of Shear Stress in Intracellular Signaling.
2) Stephen Wu (1999) Role of Cytoskeleton and Deformability in Cell Rolling.
3) Steven Brooks (1997) Laminar Flow Past an Array of Cells That are Adherent to the Bottom Plate of a Flow Channel.